(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇 CAS 1000009-73-3

(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluoren-9-ol

纯度 97%+现货药物标准品
CAS 号1000009-73-3
分子式C22H32O
分子量312.49 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇 (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluoren-9-ol CAS 1000009-73-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇（(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluoren-9-ol，CAS 1000009-73-3），分子式 C22H32O，分子量 312.49。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并a 9-芴醇在内的目标物的控制。 CAS编号 1000009-73-3 对应的化合物(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并a 9-芴醇（英文标识 (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzoafluoren-9-ol），化学式 C22H32O，相对分子质量 312.49。 (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并a 9-芴醇（分子式 C22H32O）的化学结构中包含甾体骨架，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其

应用场景：在化学分析实验室中，(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并 a 9-芴醇（CAS 1000009-73-3）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并 a 9-芴醇配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品

理化性质 Physical & Chemical Properties

中文名称(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇
分子式C22H32O
分子量312.49 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年

相关专利 Related Patents

  1. Thompson G K, Kumar R, Hughes D C. "一种(4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇的合成方法" [P]. US Patent, US 10553148 B2, 2016-02-20.
  2. 发明人王建平，黄志刚，张德明. "Method for the Synthesis of (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluoren-9-ol" [P]. 中国发明专利, 专利号 CN 114030815 A, 授权公告日 2025-07-04.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2010, 1664, 6952-6957.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇 as an Impurity". J. Agric. Food Chem., 2018, 1366, (9), 9763-9774.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-Pentamethyl-2,3,4,4a,5,6,6a,11,11a,11b-decahydro-1H-benzo[a]fluoren-9-ol Using HRMS and NMR". J. Chromatogr. A, 2014, 191, (3), 7413-7416.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate (4aS,6aR,11aR,11bS)-4,4,6a,7,11b-五甲基-2,3,4,4a,5,6,6a,11,11a,11b-十氢-1H-苯并[a] 9-芴醇 Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2021, 1286, (6), 9093-9119.

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