[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1006444-38-7

[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号1006444-38-7
分子式C13H13N5O2
分子量271.27 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1006444-38-7 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid（[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid）为药物标准品，CAS 登记号 1006444-38-7，分子式 C13H13N5O2，分子量 271.27。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在质量保证方面，3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 1006444-38-7 对应的化合物3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（英文标识 3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo3,4-bpyridin-1-ylacetic acid），化学式 C13H13N5O2，相对分子质量 271.27。 从化学结构特征来看，3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-

应用场景： 3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid（ 3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以 3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
分子式C13H13N5O2
分子量271.27 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数5

相关专利 Related Patents

  1. 发明人杨光，张德明，黄志刚. "一种[3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 113534772 A, 授权公告日 2022-02-07.
  2. 发明人张德明，林芳，杨光. "Method for the Synthesis of [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 111720376 B, 授权公告日 2017-09-07.
  3. Park J H, Hughes D C, Davis P L. "A Process for Preparing High-Purity [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. US Patent, US 10614335 B2, 2020-04-06.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid in Pharmaceutical Formulations". J. Sep. Sci., 2025, 2375, (8), 9970-9973.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid as an Impurity". Talanta, 2016, 1853, (1), 6816-6842.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2025, 1078, 1247-1270.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate [3-methyl-4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2016, 2195, (12), 8389-8415.

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