ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate CAS 1049874-06-7

ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1049874-06-7
分子式C12H12N4O5
分子量292.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate CAS 1049874-06-7 结构式 Chemical Structure

产品介绍 Description

ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate（英文名 ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate，CAS 1049874-06-7）属于药物标准品。分子式 C12H12N4O5，分子量 292.25。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate在内的目标物的控制。 CAS编号 1049874-06-7 对应的化合物ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate（英文标识 ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate），化学式 C12H12N4O5，相对分子质量 292.25。 ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate（分子式 C12H12N4O5）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DA

应用场景：在化学分析实验室中，ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate（CAS 1049874-06-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将

理化性质 Physical & Chemical Properties

中文名称ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate
分子式C12H12N4O5
分子量292.25 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数4

相关专利 Related Patents

  1. Chen K W, Klinger H, O'Brien P Q. "一种ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate的合成方法" [P]. US Patent, US 11072171 B2, 2018-10-26.
  2. Klinger H, Patel M V, O'Brien P Q. "Method for the Synthesis of ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate" [P]. US Patent, US 9626645 B2, 2023-09-05.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate in Pharmaceutical Formulations". Sci. Total Environ., 2019, 2409, (9), 8624-8652.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate as an Impurity". J. Chromatogr. A, 2024, 924, 5196-5205.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate Using HRMS and NMR". J. Nat. Prod., 2020, 1976, (2), 2725-2739.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate ethyl 1-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2023, 1733, 6451-6462.

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