CAS 10584-64-2

10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911

纯度 97%+现货药物标准品
CAS 号10584-64-2
分子式C26H32O6
分子量440.53 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911 CAS 10584-64-2 结构式 Chemical Structure

产品介绍 Description

（10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911，CAS 号 10584-64-2）是 CATO 佳途自主生产的药物标准品，分子式 C26H32O6，分子量 440.53。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C26H32O6 的（10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309

应用场景：针对化学分析用途，（10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETOD

理化性质 Physical & Chemical Properties

中文名称
分子式C26H32O6
分子量440.53 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1960年

相关专利 Related Patents

  1. 发明人张德明，郭海燕，陈志强. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 111756528 B, 授权公告日 2024-02-23.
  2. 发明人周伟，钱学锋，林芳. "Method for the Synthesis of 10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911" [P]. 中国发明专利, 专利号 CN 111959133 A, 授权公告日 2016-08-20.
  3. Anderson J P, Mueller T, Davis P L. "A Process for Preparing High-Purity 10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911" [P]. US Patent, US 9373354 B2, 2017-03-12.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Talanta, 2025, 1415, (10), 2654-2666.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chim. Acta, 2019, 1038, (9), 3023-3053.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 10584-64-2 16,13.alpha.,14.beta.,17.alpha.-chola-20,22-dien-16-oic acid, 14,15.beta.:21,23-diepoxy-17-hydroxy-4,4,8-trimethyl-3,7-dioxo-, .delta.-lactone D-Homo-24-nor-17-oxachola-20,7,16-trione, 14,15:21,23-diepoxy-4,4,8-trimethyl-, (5.alpha.,13.alpha.,14.beta.,15.beta.,17a.alpha.)- KETODIHYDROGENDUNIN NSC-309911 NSC309911 Using HRMS and NMR". J. Chromatogr. A, 2011, 680, (3), 5194-5206.

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