Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate CAS 109348-94-9
Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate
| CAS 号 | 109348-94-9 |
| 分子式 | C8H10N4S5 |
| 分子量 | 322.52 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CATO 佳途供应的Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate（Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate）为药物标准品，CAS 登记号 109348-94-9，分子式 C8H10N4S5，分子量 322.52。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 CAS编号 109348-94-9 对应的化合物Ethyl {3-(methylthio)-1,2,4-thiadiazol-5-ylthiomethyl} cyanocarbonimidodithioate（英文标识 Ethyl {3-(methylthio)-1,2,4-thiadiazol-5-ylthiomethyl} cyanocarbonimidodithioate），化学式 C8H10N4S5，相对分子质量 322.52。 从化学结构特征来看，Ethyl {3-(methylthio)-1,2,4-thiadiazol-5-ylthiomethyl} cyanocarbonimidodithioate的分子骨架中包含含氮杂环结构，含氰基，含硫有机。该化合物的不饱和度为6.0，表明结构中存在约6个环或双键等价单元。分子量为322.52 g/mol，属于较高分子量化合物。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效
应用场景：从实际应用出发，Ethyl { 3-(methylthio)-1,2,4-thiadiazol-5-ylthio methyl} cyanocarbonimidodithioate（CAS 109348-94-9）在化学分析中作为关键的基准对照物质。 推荐以Ethyl { 3-(methylthio)-1,2,4-thiadiazol-5-ylthio methyl} cyanocarbonimidodithioate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温
理化性质 Physical & Chemical Properties
| 中文名称 | Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate |
| 分子式 | C8H10N4S5 |
| 分子量 | 322.52 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1988年 |
| 含氮原子数 | 4 |
| 含硫原子数 | 5 |
相关专利 Related Patents
- 发明人朱建伟，钱学锋，杨光. "一种Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate的合成方法" [P]. 中国发明专利, 专利号 CN 112108722 B, 授权公告日 2020-09-22.
- 发明人徐明华，陈志强，郑宇鹏. "Method for the Synthesis of Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate" [P]. 中国发明专利, 专利号 CN 108571092 A, 授权公告日 2020-02-01.
参考文献 Literature
- Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate in Pharmaceutical Formulations". J. Agric. Food Chem., 2015, 586, 3935-3954.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate as an Impurity". Talanta, 2022, 2266, (3), 1331-1357.
- Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate Using HRMS and NMR". J. Chromatogr. A, 2015, 1644, (8), 68-96.
- Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate Ethyl {[3-(methylthio)-1,2,4-thiadiazol-5-ylthio]methyl} cyanocarbonimidodithioate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2018, 2292, (12), 4102-4116.
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