CAS 110480-13-2

(2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec

纯度 97%+现货药物标准品
CAS 号110480-13-2
分子式C39H69NO12
分子量743.96 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec CAS 110480-13-2 结构式 Chemical Structure

产品介绍 Description

（英文名 (2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec，CAS 110480-13-2）属于药物标准品。分子式 C39H69NO12，分子量 743.96。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 110480-13-2 对应的化合物（英文标识 (2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yloxy-11-(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-methyl(propan-2-yl)aminooxan-2-yloxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo10.2.1pentadec），化学式 C39H69NO12，相对分子质量 743.96。 从化学结构特征来看，的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为6.0，表明结构中存在约6个环或双键等价单元。分子量为743.96 g/mol，属于高分子量化合物。由于结构中存在共轭发色团，该化合物在2

应用场景：针对化学分析用途，（(2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9- (2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl oxy-11- (2S,3R,4S,6R)-3-hydroxy-6-methyl-4- methyl(propan-2-yl)amino oxan-2-yl oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo 10.2.1 pentadec）是具有明确定量溯源的认证级对照品。 推荐以配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称
分子式C39H69NO12
分子量743.96 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数1

相关专利 Related Patents

  1. Park J H, Chen K W, Klinger H. "一种的合成方法" [P]. US Patent, US 9690419 B2, 2023-05-20.
  2. 发明人胡光，赵玉洁，王建平. "Method for the Synthesis of (2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec" [P]. 中国发明专利, 专利号 CN 111922486 B, 授权公告日 2018-03-26.
  3. 发明人罗永刚，黄志刚，郭海燕. "A Process for Preparing High-Purity (2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec" [P]. 中国发明专利, 专利号 CN 108526296 A, 授权公告日 2024-03-03.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Food Chem., 2020, 547, 412-419.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2016, 1068, 7538-7555.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of (2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-9-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-11-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-[methyl(propan-2-yl)amino]oxan-2-yl]oxy-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec Using HRMS and NMR". Phytochemistry, 2024, 2059, 6973-6997.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2013, 2115, (1), 1833-1848.

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