CAS 129783-50-2

Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane]

纯度 97%+现货药物标准品
CAS 号129783-50-2
分子式C15H12Br4O2 C21H24O4 C6H8N2O2S C3H5ClO
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane] CAS 129783-50-2 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的（Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane]）为药物标准品，CAS 登记号 129783-50-2，分子式 C15H12Br4O2 C21H24O4 C6H8N2O2S C3H5ClO。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在质量保证方面，的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 129783-50-2 对应的化合物（英文标识 Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis2,6-dibromophenol and 2,2'-(1-methylethylidene)bis(4,1-phenyleneoxymethylene)bisoxirane），化学式 C15H12Br4O2 C21H24O4 C6H8N2O2S C3H5ClO，相对分子质量 1149.02。 从化学结构特征来看，的分子骨架中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氯/溴取代。该化合物的不饱和度为20.0，表明结构中存在约20个环

应用场景：（Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis 2,6-dibromophenol and 2,2'- (1-methylethylidene)bis(4,1-phenyleneoxymethylene) bis oxirane ，CAS 129783-50-2）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀

理化性质 Physical & Chemical Properties

中文名称
分子式C15H12Br4O2 C21H24O4 C6H8N2O2S C3H5ClO
分子量1149.02 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）20.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量Cl/Br取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Kumar R, Davis P L, O'Brien P Q. "一种的合成方法" [P]. US Patent, US 10871340 B2, 2018-08-28.
  2. O'Brien P Q, Patel M V, Williams B T. "Method for the Synthesis of Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane]" [P]. US Patent, US 10787442 B2, 2021-04-22.
  3. Schröder R, Sørensen M, Martínez F. "A Process for Preparing High-Purity Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane]" [P]. European Patent, EP 3211528 A1, 2021-09-14.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chim. Acta, 2023, 1674, (10), 715-734.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Agric. Food Chem., 2010, 307, 7885-7893.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of Benzenesulfonamide, 4-amino-, polymer with 2-(chloromethyl)oxirane, 4,4'-(1-methylethylidene)bis[2,6-dibromophenol] and 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis[oxirane] Using HRMS and NMR". Food Chem., 2019, 1502, (6), 6209-6212.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2015, 1994, (3), 7014-7041.

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