ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 14757-98-3

ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

纯度 97%+现货药物标准品
CAS 号14757-98-3
分子式C9H13BrN2O3
分子量277.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 14757-98-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate，CAS 14757-98-3），分子式 C9H13BrN2O3，分子量 277.12。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 化学式为 C9H13BrN2O3 的ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate），其CAS登记号是 14757-98-3，分子量为 277.12 g/mol。 ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（C9H13BrN2O3）含有含氮杂环结构，酰胺类，含羟基，含醚键，含溴取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性

应用场景：ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate（ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate，CAS 14757-98-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate配制标准系列工作溶液，用于建立标准

理化性质 Physical & Chemical Properties

中文名称ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
分子式C9H13BrN2O3
分子量277.12 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1961年
卤素含量Br取代
含氮原子数2

相关专利 Related Patents

  1. 发明人李文辉，钱学锋，郭海燕. "一种ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 117490552 B, 授权公告日 2021-05-24.
  2. Patel M V, Lee S K, Thompson G K. "Method for the Synthesis of ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate" [P]. US Patent, US 11634815 B2, 2022-08-07.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate in Pharmaceutical Formulations". Sci. Total Environ., 2022, 1034, (2), 9044-9060.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate as an Impurity". Rapid Commun. Mass Spectrom., 2022, 955, (3), 6039-6059.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Using HRMS and NMR". Chemosphere, 2022, 2396, (12), 6184-6199.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate ethyl 6-(bromomethyl)-4-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2011, 1694, (8), 5832-5836.

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