(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 CAS 149989-68-4

(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

纯度 97%+现货药物标准品
CAS 号149989-68-4
分子式C58H76N7O10PSi
分子量1090.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite CAS 149989-68-4 结构式 Chemical Structure

产品介绍 Description

(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite）是药物分析与质量控制领域常用的药物标准品，CAS 号 149989-68-4。分子式 C58H76N7O10PSi，分子量 1090.32。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺在内的目标物的控制。 (2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylp

应用场景：(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺（(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofura

理化性质 Physical & Chemical Properties

中文名称(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
分子式C58H76N7O10PSi
分子量1090.32 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）24.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1999年
含氮原子数7

相关专利 Related Patents

  1. 发明人郭海燕，唐晓军，郑宇鹏. "一种(2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺的合成方法" [P]. 中国发明专利, 专利号 CN 114171198 B, 授权公告日 2024-07-03.
  2. Jørgensen K, Johansson L, Mueller T C. "Method for the Synthesis of (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite" [P]. European Patent, EP 3623745 A1, 2019-10-01.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of (2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 in Pharmaceutical Formulations". Talanta, 2025, 1866, (1), 926-952.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(4-(2-(4-(叔丁基)苯氧基)乙酰胺基)-2-氧代嘧啶-1(2H)-基)-4-((叔丁基二甲基硅烷基)氧基)四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺 as an Impurity". J. Agric. Food Chem., 2022, 1711, (11), 5061-5078.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(2-(4-(tert-butyl)phenoxy)acetamido)-2-oxopyrimidin-1(2H)-yl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Using HRMS and NMR". J. Chromatogr. A, 2018, 2436, 509-533.

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