N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide CAS 1541606-87-4

N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide

纯度 97%+现货药物标准品
CAS 号1541606-87-4
分子式C9H15N5O2
分子量225.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide CAS 1541606-87-4 结构式 Chemical Structure

产品介绍 Description

N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide（英文名 N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide，CAS 1541606-87-4）属于药物标准品。分子式 C9H15N5O2，分子量 225.25。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

依据分子式为 C9H15N5O2 的N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-1,2,4triazolo4,3-apiperazin-2-yl}acetamide结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 225.25 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-1,2,4triazolo4,3-apiperazin-2-yl}acetamide（N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-1,2,4triazolo4,3-apiperazin-2-yl}acetamide），CAS注册编号 1541606-87-4，化学分子式为 C9H15N5O2，分子量 225.25 g/mol。 推荐用于分析方法开发与验证

应用场景：针对化学分析用途，N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H- 1,2,4 triazolo 4,3-a piperazin-2-yl}acetamide（N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H- 1,2,4 triazolo 4,3-a piperazin-2-yl}acetamide）是具有明确定量溯源的认证级对照品。 推荐以N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H- 1,2,4 triazolo 4,3-a piperazin-2-yl}acetamide配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide
分子式C9H15N5O2
分子量225.25 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
含氮原子数5

相关专利 Related Patents

  1. 发明人张德明，徐明华，林芳. "一种N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide的合成方法" [P]. 中国发明专利, 专利号 CN 112670742 A, 授权公告日 2025-10-14.
  2. Sørensen M, Jørgensen K, Mueller T C. "Method for the Synthesis of N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide" [P]. European Patent, EP 3959241 A1, 2017-09-04.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2018, 1589, 7892-7908.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide as an Impurity". Anal. Chem., 2020, 2144, (8), 2496-2519.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide Using HRMS and NMR". J. Sep. Sci., 2018, 2122, (1), 2461-2480.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate N,N-dimethyl-2-{3-oxo-2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]piperazin-2-yl}acetamide Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2019, 1978, (3), 2929-2954.

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