3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione CAS 1542815-85-9

3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione

纯度 97%+现货药物标准品
CAS 号1542815-85-9
分子式C14H17N3O2
分子量259.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione CAS 1542815-85-9 结构式 Chemical Structure

产品介绍 Description

CAS 1542815-85-9 对应的3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione（3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione）为 CATO 佳途药物标准品产品线成员。分子式 C14H17N3O2，分子量 259.30。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），3-3-(aminomethyl)phenyl-5-cyclopropyl-5-methylimidazolidine-2,4-dione满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 3-3-(aminomethyl)phenyl-5-cyclopropyl-5-methylimidazolidine-2,4-dione（3-3-(aminomethyl)phenyl-5-cyclopropyl-5-methylimidazolidine-2,4-dione），CAS注册编号 1542815-85-9，化学分子式为 C14H17N3O2，分子量 259.30 g/mol。 从化学结构特征来看，3-3-(aminomethyl)phenyl-5-cyclopropyl-5-methylimidazolidine-2,4-dione的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和

应用场景：针对化学分析用途，3- 3-(aminomethyl)phenyl -5-cyclopropyl-5-methylimidazolidine-2,4-dione（3- 3-(aminomethyl)phenyl -5-cyclopropyl-5-methylimidazolidine-2,4-dione）是具有明确定量溯源的认证级对照品。 推荐以3- 3-(aminomethyl)phenyl -5-cyclopropyl-5-methylimidazolidine-2,4-dione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据

理化性质 Physical & Chemical Properties

中文名称3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione
分子式C14H17N3O2
分子量259.30 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
含氮原子数3

相关专利 Related Patents

  1. 发明人朱建伟，刘建华，郑宇鹏. "一种3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione的合成方法" [P]. 中国发明专利, 专利号 CN 110932923 B, 授权公告日 2021-06-15.
  2. Johnson M A, Patel M V, Williams B T. "Method for the Synthesis of 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione" [P]. US Patent, US 11765774 B2, 2017-02-01.
  3. Davis P L, Patel M V, Yamamoto T. "A Process for Preparing High-Purity 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione" [P]. US Patent, US 9197534 B2, 2021-12-14.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione in Pharmaceutical Formulations". Anal. Chim. Acta, 2020, 845, (4), 4992-5022.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione as an Impurity". J. Agric. Food Chem., 2010, 1155, (7), 2930-2942.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione Using HRMS and NMR". Chemosphere, 2012, 629, (1), 6732-6743.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 3-[3-(aminomethyl)phenyl]-5-cyclopropyl-5-methylimidazolidine-2,4-dione Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2017, 1406, 2890-2895.

Related aminomethyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...