CAS 172927-65-0

172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001

纯度 97%+现货药物标准品
CAS 号172927-65-0
分子式C20H28N4O6
分子量420.46 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001 CAS 172927-65-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001，CAS 172927-65-0），分子式 C20H28N4O6，分子量 420.46。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

（C20H28N4O6）含有黄酮骨架，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 化学式为 C20H28N4O6 的（172927-65-0 Sibrafiban USAN:INN:BAN ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-al

应用场景：（172927-65-0 Sibrafiban USAN:INN:BAN ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)

理化性质 Physical & Chemical Properties

中文名称
分子式C20H28N4O6
分子量420.46 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2006年
含氮原子数4

相关专利 Related Patents

  1. 发明人郭海燕，钱学锋，赵玉洁. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 117959151 A, 授权公告日 2023-09-18.
  2. Klinger H, Mueller T, Davis P L. "Method for the Synthesis of 172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001" [P]. US Patent, US 9679198 B2, 2016-04-28.
  3. 发明人郑宇鹏，钱学锋，周伟. "A Process for Preparing High-Purity 172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001" [P]. 中国发明专利, 专利号 CN 109545399 A, 授权公告日 2018-09-14.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Chromatogr. A, 2013, 1440, (1), 4524-4551.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Pharm. Biomed. Anal., 2022, 1799, 8116-8138.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 172927-65-0 Sibrafiban [USAN:INN:BAN] ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)acetic acid ethyl ester Ro 48-3657 Sibrafiban Acetic acid, ((1-(2-((4-(amino(hydroxyimino)methyl)benzoyl)amino)-1-oxopropyl)-4-piperidinyl)oxy)-, ethyl ester, (S-(Z))- Ethyl (Z)-((1-(N-((p-hydroxyamidino)benzoyl)-L-alanyl)-4-piperidyl)oxy)acetate RO 48-3657/001 Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 2211, 9374-9377.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2025, 2184, (11), 5461-5482.

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