2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE CAS 174258-39-0

2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE

纯度 97%+现货药物标准品
CAS 号174258-39-0
分子式C12H9ClF3NO
分子量275.65 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE CAS 174258-39-0 结构式 Chemical Structure

产品介绍 Description

CAS 174258-39-0 对应的2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE（2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE）为 CATO 佳途药物标准品产品线成员。分子式 C12H9ClF3NO，分子量 275.65。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE（2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE），CAS注册编号 174258-39-0，化学分子式为 C12H9ClF3NO，分子量 275.65 g/mol。 从化学结构特征来看，2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为275.65 g/mol，属于中等分子量化合物。卤素原子的引入增加了化合物的电负性，在ECD（电子捕获检测

应用场景：2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE（2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE，CAS 174258-39-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： -

理化性质 Physical & Chemical Properties

中文名称2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE
分子式C12H9ClF3NO
分子量275.65 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2006年
卤素含量F/Cl取代
含氮原子数1

相关专利 Related Patents

  1. Fischer A B, Mueller T, Kumar R. "一种2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE的合成方法" [P]. US Patent, US 11656995 B2, 2018-09-14.
  2. Johnson M A, Klinger H, Stevens L M. "Method for the Synthesis of 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE" [P]. US Patent, US 10063452 B2, 2025-02-17.
  3. 发明人林芳，赵玉洁，徐明华. "A Process for Preparing High-Purity 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE" [P]. 中国发明专利, 专利号 CN 114496213 A, 授权公告日 2024-09-21.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2013, 1932, (12), 8965-8970.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE as an Impurity". Biomed. Chromatogr., 2024, 758, (9), 2074-2079.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE Using HRMS and NMR". Anal. Chim. Acta, 2022, 1690, 2395-2399.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 2-(4-TRIFLUOROMETHYLPHENYL)-4-CHLOROMETHYL-5-METHYLOXAZOLE Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2025, 1694, (6), 8095-8099.

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