methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate CAS 1807939-06-5

methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1807939-06-5
分子式C7H10ClFO4S
分子量244.67 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate CAS 1807939-06-5 结构式 Chemical Structure

产品介绍 Description

methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate（英文名 methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate，CAS 1807939-06-5）属于药物标准品。分子式 C7H10ClFO4S，分子量 244.67。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

methyl (1s,3s)-3-(chlorosulfonyl)methyl-3-fluorocyclobutane-1-carboxylate的产生途径与其化学式中含砜基，羧酸类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 methyl (1s,3s)-3-(chlorosulfonyl)methyl-3-fluorocyclobutane-1-carboxylate（methyl (1s,3s)-3-(chlorosulfonyl)methyl-3-fluorocyclobutane-1-carboxylate），CAS注册编号 1807939-06-5，化学分子式为 C7H10ClFO4S，分子量 244.67 g/mol。 methyl (1s,3s)-3-(chlorosulfonyl)methyl-3-fluorocyclobutane-1-carboxylate（分子式 C7H10ClFO4S）的化学结构中包含含砜基，羧酸类，含羟基，含醚键，含氟/氯取代。在反相色谱体系中，其保留行为主要受官能团

应用场景：methyl (1s,3s)-3- (chlorosulfonyl)methyl -3-fluorocyclobutane-1-carboxylate（methyl (1s,3s)-3- (chlorosulfonyl)methyl -3-fluorocyclobutane-1-carboxylate，CAS 1807939-06-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以methyl (1s,3s)-3- (chlorosulfonyl)methyl -3-fluorocyclobutane-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。

理化性质 Physical & Chemical Properties

中文名称methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate
分子式C7H10ClFO4S
分子量244.67 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1995年
卤素含量F/Cl取代
含硫原子数1

相关专利 Related Patents

  1. Rossi M, Nowak P, Jørgensen K. "一种methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate的合成方法" [P]. European Patent, EP 3089379 A1, 2019-11-06.
  2. 发明人孙丽萍，杨光，黄志刚. "Method for the Synthesis of methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate" [P]. 中国发明专利, 专利号 CN 111851606 A, 授权公告日 2015-07-09.
  3. 发明人冯建国，赵玉洁，唐晓军. "A Process for Preparing High-Purity methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate" [P]. 中国发明专利, 专利号 CN 113910717 A, 授权公告日 2023-12-07.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2019, 412, (7), 7023-7045.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate as an Impurity". Environ. Sci. Technol., 2013, 1014, 2179-2191.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate Using HRMS and NMR". Food Chem., 2024, 885, 911-921.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate methyl (1s,3s)-3-[(chlorosulfonyl)methyl]-3-fluorocyclobutane-1-carboxylate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2025, 551, 4943-4960.

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