[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride CAS 1820583-59-2

[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1820583-59-2
分子式C9H15FN4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride [cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride CAS 1820583-59-2 结构式 Chemical Structure

产品介绍 Description

[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride（[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1820583-59-2。分子式 C9H15FN4O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

cis-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride的产生途径与其化学式中酰胺类，含羟基，含醚键，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H15FN4O 2HCl 的cis-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride（cis-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)methylpyrrolidin-2-ylmethanamine dihydrochloride），其CAS登记号是 1820583-59-2，分子量为 250.70 g/mol。 依据分子式为 C9H15FN4O 2HCl 的cis-4-fluoro-1-(5-methyl-1,2,4-oxadiazol-3-yl)m

应用场景：针对化学分析用途， cis-4-fluoro-1- (5-methyl-1,2,4-oxadiazol-3-yl)methyl pyrrolidin-2-yl methanamine dihydrochloride（ cis-4-fluoro-1- (5-methyl-1,2,4-oxadiazol-3-yl)methyl pyrrolidin-2-yl methanamine dihydrochloride）是具有明确定量溯源的认证级对照品。 推荐以 cis-4-fluoro-1- (5-methyl-1,2,4-oxadiazol-3-yl)methyl pyrrolidin-2-yl

理化性质 Physical & Chemical Properties

中文名称[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride
分子式C9H15FN4O 2*HCl
分子量250.70 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人杨光，朱建伟，李文辉. "一种[cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 114583658 A, 授权公告日 2019-02-26.
  2. Klinger H, Davis P L, Fischer A B. "Method for the Synthesis of [cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride" [P]. US Patent, US 11524915 B2, 2025-11-13.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of [cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride in Pharmaceutical Formulations". Food Chem., 2016, 1132, 849-858.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of [cis-4-fluoro-1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]pyrrolidin-2-yl]methanamine dihydrochloride as an Impurity". Chemosphere, 2018, 446, (8), 6705-6735.

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