CAS 185147-17-5

185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one

纯度 97%+现货药物标准品
CAS 号185147-17-5
分子式C17H14O5S
分子量330.36 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one CAS 185147-17-5 结构式 Chemical Structure

产品介绍 Description

（185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one）是药物分析与质量控制领域常用的药物标准品，CAS 号 185147-17-5。分子式 C17H14O5S，分子量 330.36。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 185147-17-5 对应的化合物（英文标识 185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one），化学式 C17H14O5S，相对分子质量 330.36。 （C17H14O5S）含有黄酮骨架，含砜基，含羟基，含醚键。羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。 作

应用场景：（185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one，CAS 185147-17-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以配制标准系列工作溶液，用于建立标

理化性质 Physical & Chemical Properties

中文名称
分子式C17H14O5S
分子量330.36 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2009年
含硫原子数1

相关专利 Related Patents

  1. Davis P L, Kumar R, Fischer A B. "一种的合成方法" [P]. US Patent, US 10013869 B2, 2016-08-20.
  2. 发明人刘建华，冯建国，杨光. "Method for the Synthesis of 185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one" [P]. 中国发明专利, 专利号 CN 111183989 B, 授权公告日 2018-08-23.
  3. 发明人郭海燕，冯建国，钱学锋. "A Process for Preparing High-Purity 185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one" [P]. 中国发明专利, 专利号 CN 116624512 B, 授权公告日 2019-04-17.

参考文献 Literature

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  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2020, 1409, (11), 5982-6011.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 185147-17-5 8DJV9U9K61 5-Hydroxyrofecoxib UNII-8DJV9U9K61 2(5H)-Furanone, 5-hydroxy-4-(4-(methylsulfonyl)phenyl)-3-phenyl- Rofecoxib metabolite 5-hydroxyrofecoxib J1.426.755G 5-Hydroxy-3-phenyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one Using HRMS and NMR". Anal. Methods, 2018, 2205, 3101-3120.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2021, 1953, 8807-8828.

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