3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride CAS 1864063-69-3

3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride

纯度 97%+现货药物标准品
CAS 号1864063-69-3
分子式C14H26N2O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride CAS 1864063-69-3 结构式 Chemical Structure

产品介绍 Description

3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride（3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1864063-69-3。分子式 C14H26N2O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

CAS编号 1864063-69-3 对应的化合物3-{4-(dimethylamino)methylpiperidin-1-yl}cyclohexan-1-one dihydrochloride（英文标识 3-{4-(dimethylamino)methylpiperidin-1-yl}cyclohexan-1-one dihydrochloride），化学式 C14H26N2O 2HCl，相对分子质量 274.83。 依据分子式为 C14H26N2O 2HCl 的3-{4-(dimethylamino)methylpiperidin-1-yl}cyclohexan-1-one dihydrochloride结构特征，其分子内含酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在红外光谱中会呈现特征性的官能团伸缩振动信号。分子量 274.83 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。因分子内存在卤素取代基（F/Cl/Br/I），该化合物在质谱分析中呈现特征性的同位素分布模式，可作为定性确认的重要依据。 本品适用于HPLC、GC、LC-

应用场景：3-{4- (dimethylamino)methyl piperidin-1-yl}cyclohexan-1-one dihydrochloride（3-{4- (dimethylamino)methyl piperidin-1-yl}cyclohexan-1-one dihydrochloride，CAS 1864063-69-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-{4- (dimethylamino)methyl piperidin-1-yl}cyclohexan-1-one dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。

理化性质 Physical & Chemical Properties

中文名称3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride
分子式C14H26N2O 2*HCl
分子量274.83 g/mol
外观形态白色至类白色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人林芳，高志强，孙丽萍. "一种3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 108442101 A, 授权公告日 2016-11-26.
  2. 发明人马晓峰，杨光，何建平. "Method for the Synthesis of 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride" [P]. 中国发明专利, 专利号 CN 112709085 B, 授权公告日 2024-01-01.
  3. 发明人何建平，韩伟，沈红梅. "A Process for Preparing High-Purity 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride" [P]. 中国发明专利, 专利号 CN 114372434 A, 授权公告日 2017-01-15.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2017, 1423, (9), 5638-5658.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride as an Impurity". Phytochemistry, 2021, 1740, (8), 2796-2813.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride Using HRMS and NMR". Sci. Total Environ., 2020, 1026, 4228-4240.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 3-{4-[(dimethylamino)methyl]piperidin-1-yl}cyclohexan-1-one dihydrochloride Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2022, 1355, 6925-6929.

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