rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride CAS 1909293-71-5

rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride

纯度 97%+现货药物标准品
CAS 号1909293-71-5
分子式C10H9F2NO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride CAS 1909293-71-5 结构式 Chemical Structure

产品介绍 Description

rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride（英文名 rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride，CAS 1909293-71-5）属于药物标准品。分子式 C10H9F2NO2 HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代的影响，rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo7.4.0.0^{3,7}trideca-1(13),9,11-triene hydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）。其固体形态的物理化学属性——包括249.64 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 CAS编号 1909293-71-5 对应的化合物rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo7.4.0.0^{3,7}trideca-1(13),9,11-triene hydrochloride（英文标识 rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo7.4.0.0^{

应用场景：针对化学分析用途，rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo 7.4.0.0^{3,7} trideca-1(13),9,11-triene hydrochloride（rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo 7.4.0.0^{3,7} trideca-1(13),9,11-triene hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo 7.4.0.0^

理化性质 Physical & Chemical Properties

中文名称rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride
分子式C10H9F2NO2 HCl
分子量249.64 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F/Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人林芳，黄志刚，唐晓军. "一种rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 110026409 B, 授权公告日 2016-02-25.
  2. 发明人何建平，张德明，周伟. "Method for the Synthesis of rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride" [P]. 中国发明专利, 专利号 CN 109083738 B, 授权公告日 2025-02-19.
  3. 发明人唐晓军，孙丽萍，陈志强. "A Process for Preparing High-Purity rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride" [P]. 中国发明专利, 专利号 CN 116084137 B, 授权公告日 2021-05-26.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2020, 1526, 6142-6164.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride as an Impurity". Talanta, 2020, 1928, (6), 4951-4978.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride Using HRMS and NMR". Anal. Methods, 2011, 1158, (8), 4575-4580.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate rac-(3R,7S)-10,13-difluoro-2,8-dioxa-5-azatricyclo[7.4.0.0^{3,7}]trideca-1(13),9,11-triene hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2023, 1171, 7239-7253.

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