4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride CAS 1909348-01-1

4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride

纯度 97%+现货药物标准品
CAS 号1909348-01-1
分子式C13H18N2O2 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride CAS 1909348-01-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride（4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride，CAS 1909348-01-1），分子式 C13H18N2O2 2*HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括4-hydroxy-3-(4-methylpiperazin-1-yl)methylbenzaldehyde dihydrochloride在内的目标物的控制。 CAS编号 1909348-01-1 对应的化合物4-hydroxy-3-(4-methylpiperazin-1-yl)methylbenzaldehyde dihydrochloride（英文标识 4-hydroxy-3-(4-methylpiperazin-1-yl)methylbenzaldehyde dihydrochloride），化学式 C13H18N2O2 2HCl，相对分子质量 270.76。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代的影响，4-hydroxy-3-(4-methylpiperazin-1-yl)methylbenzaldehyde dihydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）。其固体形态的物理化学属性——包括270.76 g/mol的分子量——对于选

应用场景：4-hydroxy-3- (4-methylpiperazin-1-yl)methyl benzaldehyde dihydrochloride（4-hydroxy-3- (4-methylpiperazin-1-yl)methyl benzaldehyde dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以4-hydroxy-3- (4-methylpiperazin-1-yl)methyl benzaldehyde dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液

理化性质 Physical & Chemical Properties

中文名称4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride
分子式C13H18N2O2 2*HCl
分子量270.76 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人陈志强，李文辉，刘建华. "一种4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 113066601 B, 授权公告日 2016-07-24.
  2. 发明人孙丽萍，李文辉，胡光. "Method for the Synthesis of 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride" [P]. 中国发明专利, 专利号 CN 117845655 A, 授权公告日 2017-09-17.
  3. Sørensen M, Johansson L, Martínez F. "A Process for Preparing High-Purity 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride" [P]. European Patent, EP 3535514 A1, 2023-03-28.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2012, 303, (9), 6228-6250.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride as an Impurity". J. Pharm. Biomed. Anal., 2015, 2072, 2578-2585.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride Using HRMS and NMR". Anal. Methods, 2013, 1100, 9368-9372.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]benzaldehyde dihydrochloride Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2022, 911, 2694-2697.

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