(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺 CAS 192126-76-4
(R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide
| CAS 号 | 192126-76-4 |
| 分子式 | C17H30N2O12S |
| 分子量 | 486.49 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺（英文名 (R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide，CAS 192126-76-4）属于药物标准品。分子式 C17H30N2O12S，分子量 486.49。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺在内的目标物的控制。 (R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺（(R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide），CAS注册编号 192126-76-4，化学分子式为 C17H30N2O12S，分子量 486.49 g/mo
应用场景：从实际应用出发，(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺（CAS 192126-76-4）在化学分析中作为关键的基准对照物质。 推荐以(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺配制标准系列工作溶液，用于建立标准曲线实现外标法定量。
理化性质 Physical & Chemical Properties
| 中文名称 | (R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺 |
| 分子式 | C17H30N2O12S |
| 分子量 | 486.49 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2011年 |
| 含氮原子数 | 2 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- 发明人郭海燕，徐明华，李文辉. "一种(R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺的合成方法" [P]. 中国发明专利, 专利号 CN 113861746 A, 授权公告日 2015-04-15.
- Lefèvre J P, Nielsen H, Sørensen M. "Method for the Synthesis of (R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide" [P]. European Patent, EP 3715161 A1, 2015-08-07.
- 发明人李文辉，朱建伟，张德明. "A Process for Preparing High-Purity (R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide" [P]. 中国发明专利, 专利号 CN 110667254 A, 授权公告日 2016-06-07.
参考文献 Literature
- Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of (R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺 in Pharmaceutical Formulations". Chromatographia, 2015, 2221, (1), 6247-6256.
- Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (R)-2-乙酰氨基-N-((2R,3R,4R,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-五羟基环己基)氧基)四氢-2H-吡喃-3-基)-3-巯基丙酰胺 as an Impurity". Talanta, 2013, 1931, (5), 6563-6572.
- Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (R)-2-Acetamido-N-((2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)tetrahydro-2H-pyran-3-yl)-3-mercaptopropanamide Using HRMS and NMR". J. Sep. Sci., 2010, 336, (9), 8668-8682.
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