CAS 192185-72-1

(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE D07NPS JAN R 115777 R-11577 R-115777 R115777 Tipifarnib Tipifarnib (USAN/INN) Tipifarnib [USAN] Zarnestra Zarnestra, IND 58359, R115777, Tipifarnib

纯度 97%+现货药物标准品
CAS 号192185-72-1
分子式C27H22Cl2N4O
分子量489.40 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE D07NPS JAN R 115777 R-11577 R-115777 R115777 Tipifarnib Tipifarnib (USAN/INN) Tipifarnib [USAN] Zarnestra Zarnestra, IND 58359, R115777, Tipifarnib CAS 192185-72-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE D07NPS JAN R 115777 R-11577 R-115777 R115777 Tipifarnib Tipifarnib (USAN/INN) Tipifarnib [USAN] Zarnestra Zarnestra, IND 58359, R115777, Tipifarnib，CAS 192185-72-1），分子式 C27H22Cl2N4O，分子量 489.40。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，的分子量为489.40 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C27H22Cl2N4O 的（(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl

应用场景：（(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6- (R)-amino(4-chlorophenyl)(1-methyl-1

理化性质 Physical & Chemical Properties

中文名称
分子式C27H22Cl2N4O
分子量489.40 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）18.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2011年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人高志强，刘建华，唐晓军. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 113432992 B, 授权公告日 2016-07-12.
  2. 发明人郭海燕，孙丽萍，朱建伟. "Method for the Synthesis of (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE D07NPS JAN R 115777 R-11577 R-115777 R115777 Tipifarnib Tipifarnib (USAN/INN) Tipifarnib [USAN] Zarnestra Zarnestra, IND 58359, R115777, Tipifarnib" [P]. 中国发明专利, 专利号 CN 110069223 A, 授权公告日 2015-03-18.
  3. 发明人杨光，陈志强，郑宇鹏. "A Process for Preparing High-Purity (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone (R)-R115777 192185-72-1 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE D07NPS JAN R 115777 R-11577 R-115777 R115777 Tipifarnib Tipifarnib (USAN/INN) Tipifarnib [USAN] Zarnestra Zarnestra, IND 58359, R115777, Tipifarnib" [P]. 中国发明专利, 专利号 CN 116848824 A, 授权公告日 2022-09-08.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Food Chem., 2016, 2129, (3), 6800-6806.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Sep. Sci., 2021, 1895, (8), 5656-5683.

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