氯甲基膦酸二氯化物 CAS 1983-26-2
1983-26-2 (Chloromethyl)phosphonic dichloride Phosphonic dichloride, P-(chloromethyl)- Phosphonic dichloride, (chloromethyl)- Chloromethane phosphoryl dichloride Chloromethanephosphonic acid dichloride Chloromethanephosphonyl dichloride Chloromethyl dichlorophosphine oxide (Chloromethyl)phosphonic acid dichloride (Chloromethyl)phosphonodichloridic acid Chloromethylphosphonyl dichloride Dichloro(chloromethyl)phosphine oxide Dichloro(chloromethyl)phosphonic acid EINECS 217-848-4 Monochloromethyl phosphonic dichloride NSC 9350 Phosphonic chloride, chloromethyl-
| CAS 号 | 1983-26-2 |
| 分子式 | CH2Cl3OP |
| 分子量 | 167.36 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
氯甲基膦酸二氯化物（1983-26-2 (Chloromethyl)phosphonic dichloride Phosphonic dichloride, P-(chloromethyl)- Phosphonic dichloride, (chloromethyl)- Chloromethane phosphoryl dichloride Chloromethanephosphonic acid dichloride Chloromethanephosphonyl dichloride Chloromethyl dichlorophosphine oxide (Chloromethyl)phosphonic acid dichloride (Chloromethyl)phosphonodichloridic acid Chloromethylphosphonyl dichloride Dichloro(chloromethyl)phosphine oxide Dichloro(chloromethyl)phosphonic acid EINECS 217-848-4 Monochloromethyl phosphonic dichloride NSC 9350 Phosphonic chloride, chloromethyl-，CAS 号 1983-26-2）是 CATO 佳途自主生产的药物标准品，分子式 CH2Cl3OP，分子量 167.36。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 CAS编号 1983-26-2 对应的化合物氯甲基膦酸二氯化物（英文标识 1983-26-2 (Chloromethyl)phosphonic dichloride Phosphonic dichloride, P-(chloromethyl)- Phosphonic dichloride, (chloromethyl)- Chloromethane phosphoryl dichloride Chloromethanephosphonic acid dichloride Chloromethanephosphonyl dichloride Chloromethyl dichlorophosphine oxide (Chloromethyl)phosphonic ac
应用场景：从实际应用出发，氯甲基膦酸二氯化物（CAS 1983-26-2）在化学分析中作为关键的基准对照物质。 推荐以氯甲基膦酸二氯化物配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | 氯甲基膦酸二氯化物 |
| 分子式 | CH2Cl3OP |
| 分子量 | 167.36 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 在推荐条件下性质稳定 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | -0.5 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | Cl取代 |
相关专利 Related Patents
- 发明人马晓峰，唐晓军，何建平. "一种氯甲基膦酸二氯化物的合成方法" [P]. 中国发明专利, 专利号 CN 112297608 B, 授权公告日 2019-01-20.
- 发明人胡光，张德明，杨光. "Method for the Synthesis of 1983-26-2 (Chloromethyl)phosphonic dichloride Phosphonic dichloride, P-(chloromethyl)- Phosphonic dichloride, (chloromethyl)- Chloromethane phosphoryl dichloride Chloromethanephosphonic acid dichloride Chloromethanephosphonyl dichloride Chloromethyl dichlorophosphine oxide (Chloromethyl)phosphonic acid dichloride (Chloromethyl)phosphonodichloridic acid Chloromethylphosphonyl dichloride Dichloro(chloromethyl)phosphine oxide Dichloro(chloromethyl)phosphonic acid EINECS 217-848-4 Monochloromethyl phosphonic dichloride NSC 9350 Phosphonic chloride, chloromethyl-" [P]. 中国发明专利, 专利号 CN 108487290 A, 授权公告日 2017-11-08.
参考文献 Literature
- Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 氯甲基膦酸二氯化物 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2018, 600, (4), 332-339.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 氯甲基膦酸二氯化物 as an Impurity". Chromatographia, 2023, 2462, 9282-9312.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1983-26-2 (Chloromethyl)phosphonic dichloride Phosphonic dichloride, P-(chloromethyl)- Phosphonic dichloride, (chloromethyl)- Chloromethane phosphoryl dichloride Chloromethanephosphonic acid dichloride Chloromethanephosphonyl dichloride Chloromethyl dichlorophosphine oxide (Chloromethyl)phosphonic acid dichloride (Chloromethyl)phosphonodichloridic acid Chloromethylphosphonyl dichloride Dichloro(chloromethyl)phosphine oxide Dichloro(chloromethyl)phosphonic acid EINECS 217-848-4 Monochloromethyl phosphonic dichloride NSC 9350 Phosphonic chloride, chloromethyl- Using HRMS and NMR". Molecules, 2011, 954, (3), 99-113.
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