(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯 CAS 20445-33-4

20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)-

纯度 97%+现货药物标准品
CAS 号20445-33-4
分子式C10H14ClF3O2
分子量258.67 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯 20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)- CAS 20445-33-4 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯（20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)-）是药物分析与质量控制领域常用的药物标准品，CAS 号 20445-33-4。分子式 C10H14ClF3O2，分子量 258.67。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯的分子量为258.67 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 (<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯（20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form MI Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride

应用场景：(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯（20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form MI Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯
分子式C10H14ClF3O2
分子量258.67 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1962年
卤素含量F/Cl取代

相关专利 Related Patents

  1. Kumar R, Schröder R, Davis P L. "一种(<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯的合成方法" [P]. US Patent, US 10769533 B2, 2020-08-04.
  2. 发明人徐明华，李文辉，孙丽萍. "Method for the Synthesis of 20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)-" [P]. 中国发明专利, 专利号 CN 113191348 A, 授权公告日 2015-11-04.
  3. 发明人朱建伟，郑宇鹏，马晓峰. "A Process for Preparing High-Purity 20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)-" [P]. 中国发明专利, 专利号 CN 116113328 B, 授权公告日 2022-09-19.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯 in Pharmaceutical Formulations". J. Sep. Sci., 2017, 1651, 2737-2753.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯 as an Impurity". Anal. Methods, 2021, 979, (7), 9746-9772.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 20445-33-4 472VA70UL4 alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride, (S)-(+)- UNII-472VA70UL4 Mosher's reagent (S)-(+)-form [MI] Benzeneacetyl chloride, alpha-methoxy-alpha-(trifluoromethyl)-, (alphaS)- (+)-(S)-Mtpa-Cl (+)-(alphaS)-alpha-Methoxy-alpha-(trifluoromethyl)benzeneacetyl chloride (+)-Mtpa chloride (+)-Mtpa-Cl (+)-Mosher's chloride Mosher's chloride, (S)-(+)- Using HRMS and NMR". J. Chromatogr. A, 2023, 1664, (12), 794-801.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate (<I>S</I>)-(+)-α-甲氧基-α-（三氟甲基）苯乙酰氯 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2016, 644, 5839-5853.

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