methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride CAS 2044744-91-2

methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride

纯度 97%+现货药物标准品
CAS 号2044744-91-2
分子式C7H8N2O3 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride CAS 2044744-91-2 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride（methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride，CAS 2044744-91-2），分子式 C7H8N2O3 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride在内的目标物的控制。 化学式为 C7H8N2O3 HCl 的methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride（methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride），其CAS登记号是 2044744-91-2，分子量为 204.61 g/mol。 受分子结构中酰胺类，羧酸类，含羟基，含醚键，含氯取代的影响，methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括204.61 g/mol的分子量——对于选择合适的样品前处理方

应用场景：从实际应用出发，methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride（CAS 2044744-91-2）在化学分析中作为关键的基准对照物质。 推荐以methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2

理化性质 Physical & Chemical Properties

中文名称methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride
分子式C7H8N2O3 HCl
分子量204.61 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，郑宇鹏，沈红梅. "一种methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111797213 B, 授权公告日 2024-11-21.
  2. Park J H, O'Brien P Q, Roberts E F. "Method for the Synthesis of methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride" [P]. US Patent, US 11032759 B2, 2021-03-02.
  3. 发明人何建平，徐明华，钱学锋. "A Process for Preparing High-Purity methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride" [P]. 中国发明专利, 专利号 CN 108073361 B, 授权公告日 2017-02-06.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2012, 576, 1113-1132.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride as an Impurity". J. Chromatogr. A, 2017, 1653, 4755-4764.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride Using HRMS and NMR". Molecules, 2023, 2355, (2), 7053-7080.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate methyl 5-methyl-3-oxo-3,4-dihydropyrazine-2-carboxylate hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2020, 1493, (2), 7700-7719.

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