rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid CAS 2059917-72-3

rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号2059917-72-3
分子式C9H10F3N3O2
分子量249.19 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid CAS 2059917-72-3 结构式 Chemical Structure

产品介绍 Description

rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid（英文名 rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid，CAS 2059917-72-3）属于药物标准品。分子式 C9H10F3N3O2，分子量 249.19。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo1,5-apyrimidine-3-carboxylic acid的分子量为249.19 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C9H10F3N3O2 的rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo1,5-apyrimidine-3-carboxylic acid（rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo1,5-apyrimidine-3-carboxylic acid），其CAS登记号是 2059917-72-3，分子量为 249.19 g/mol。 rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo1,5-apyrimidine-3-carboxyli

应用场景：rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo 1,5-a pyrimidine-3-carboxylic acid（rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo 1,5-a pyrimidine-3-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo 1,5-a pyrimid

理化性质 Physical & Chemical Properties

中文名称rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
分子式C9H10F3N3O2
分子量249.19 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Schröder R, O'Brien P Q, Klinger H. "一种rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid的合成方法" [P]. US Patent, US 11170937 B2, 2022-09-20.
  2. 发明人郑宇鹏，罗永刚，冯建国. "Method for the Synthesis of rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 109658586 B, 授权公告日 2023-09-18.
  3. 发明人孙丽萍，张德明，赵玉洁. "A Process for Preparing High-Purity rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113825388 A, 授权公告日 2021-11-23.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid in Pharmaceutical Formulations". J. Agric. Food Chem., 2017, 2241, 4849-4866.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid as an Impurity". Sci. Total Environ., 2014, 1703, (5), 7808-7835.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of rac-(5R,7R)-5-methyl-7-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid Using HRMS and NMR". Talanta, 2011, 257, (4), 5360-5364.

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