7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid CAS 2059936-29-5

7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid

纯度 97%+现货药物标准品
CAS 号2059936-29-5
分子式C12H18N4O4
分子量282.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid CAS 2059936-29-5 结构式 Chemical Structure

产品介绍 Description

CAS 2059936-29-5 对应的7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid（7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C12H18N4O4，分子量 282.30。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

7-(tert-butoxy)carbonyl-3-methyl-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine-6-carboxylic acid（分子式 C12H18N4O4）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 CAS编号 2059936-29-5 对应的化合物7-(tert-butoxy)carbonyl-3-methyl-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine-6-carboxylic acid（英文标识 7-(tert-butoxy)carbonyl-3-methyl-5H,6H,7H,8H-1,2,4triazolo4,3-apyrazine-6-carboxylic acid），化学式 C12H18N4O4，相对

应用场景：7- (tert-butoxy)carbonyl -3-methyl-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine-6-carboxylic acid（7- (tert-butoxy)carbonyl -3-methyl-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazine-6-carboxylic acid，CAS 2059936-29-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以7- (tert-butoxy)carbonyl -3-methyl-5H,6H,7H,8H- 1,2,4 triazolo

理化性质 Physical & Chemical Properties

中文名称7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid
分子式C12H18N4O4
分子量282.30 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
含氮原子数4

相关专利 Related Patents

  1. 发明人沈红梅，唐晓军，张德明. "一种7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 117850504 B, 授权公告日 2018-09-20.
  2. 发明人韩伟，赵玉洁，唐晓军. "Method for the Synthesis of 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid" [P]. 中国发明专利, 专利号 CN 116190031 B, 授权公告日 2017-06-17.
  3. Davis P L, Anderson J P, Mueller T. "A Process for Preparing High-Purity 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid" [P]. US Patent, US 11968073 B2, 2016-04-28.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid in Pharmaceutical Formulations". Anal. Chem., 2012, 744, (9), 2949-2978.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid as an Impurity". Sci. Total Environ., 2018, 2254, 1978-1991.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid Using HRMS and NMR". Molecules, 2021, 837, (4), 3029-3036.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 7-[(tert-butoxy)carbonyl]-3-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-6-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2011, 164, (9), 4710-4739.

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