(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP> CAS 210169-40-7

(S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500

纯度 97%+现货药物标准品
CAS 号210169-40-7
分子式C74H136O8P2
分子量1215.81 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP> (S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500 CAS 210169-40-7 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>（英文名 (S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500，CAS 210169-40-7）属于药物标准品。分子式 C74H136O8P2，分子量 1215.81。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>的分子量为1215.81 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C74H136O8P2 的(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>（(S)-(+)-4,4'-Bisdi(3,5-di-tert-butyl-4-methoxyphenyl)phosphino-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bisdi(3,5-di-tert-butyl-4-methoxyphenyl)phosphino-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500），其CAS登记号是 210169-40-7，分子量为 1215.81 g/mol。 依据分子式为 C74H136O8P2 的(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>结构特征，其分子内含含磷酸酯基，羧酸

应用场景：针对化学分析用途，(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>（(S)-(+)-4,4'-Bis di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino -3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino -4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500）是具有明确定量溯源的认证级对照品。 推

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>
分子式C74H136O8P2
分子量1215.81 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2017年

相关专利 Related Patents

  1. 发明人刘建华，韩伟，高志强. "一种(<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP>的合成方法" [P]. 中国发明专利, 专利号 CN 116855104 B, 授权公告日 2024-05-06.
  2. Brown S R, Davis P L, Park J H. "Method for the Synthesis of (S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500" [P]. US Patent, US 11671233 B2, 2020-01-05.
  3. 发明人李文辉，周伟，黄志刚. "A Process for Preparing High-Purity (S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500" [P]. 中国发明专利, 专利号 CN 114976203 B, 授权公告日 2016-11-19.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP> in Pharmaceutical Formulations". Molecules, 2017, 1586, 4108-4114.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP> as an Impurity". Anal. Chim. Acta, 2022, 912, 3885-3891.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(+)-4,4'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-3,3'-bi(1,2-methylenedioxybenzene) (S)-(+)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole (S)-(+)-DTBM-SEGPHOS(regR) 210169-40-7 D4500 Using HRMS and NMR". Sci. Total Environ., 2021, 1657, (4), 732-759.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate (<I>S</I>)-DTBM-SEGPHOS<SUP>®</SUP> Profile in Drug Substances According to ICH Guidelines". Food Chem., 2025, 1141, (12), 406-430.

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