3-氯苯并[<I>b</I>]噻吩-2-羧酸 CAS 21211-22-3
3-Chlorobenzo[b]thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene carboxylic acid 3-chloro-2-benzo[b]thiophene carboxylic acid 3-chloro-benzo[b]thio-phene-2-carboxylic acid 3-chlorobenzo [b]thiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid 21211-22-3
| CAS 号 | 21211-22-3 |
| 分子式 | C9H13ClO2S |
| 分子量 | 220.72 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3-氯苯并[<I>b</I>]噻吩-2-羧酸（英文名 3-Chlorobenzo[b]thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene carboxylic acid 3-chloro-2-benzo[b]thiophene carboxylic acid 3-chloro-benzo[b]thio-phene-2-carboxylic acid 3-chlorobenzo [b]thiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid 21211-22-3，CAS 21211-22-3）属于药物标准品。分子式 C9H13ClO2S，分子量 220.72。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
与同类药物标准品相比，3-氯苯并<I>b</I>噻吩-2-羧酸的分子量为220.72 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 3-氯苯并<I>b</I>噻吩-2-羧酸（3-Chlorobenzobthiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzobthiophene carboxylic acid 3-chloro-2-benzobthiophene carboxylic acid 3-chloro-benzobthio-phene-2-carboxylic acid 3-chlorobenzo bthiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzobthiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid
应用场景：3-氯苯并 <I>b</I> 噻吩-2-羧酸（3-Chlorobenzo b thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo b thiophene carboxylic acid 3-chloro-2-benzo b thiophene carboxylic acid 3-chloro-benzo b thio-phene-2-carboxylic acid 3-chlorobenzo b thiophene-2-carboxylic acid 3-chloro-1
理化性质 Physical & Chemical Properties
| 中文名称 | 3-氯苯并[<I>b</I>]噻吩-2-羧酸 |
| 分子式 | C9H13ClO2S |
| 分子量 | 220.72 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1963年 |
| 卤素含量 | Cl取代 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- Nielsen H, Nowak P, Kowalski A. "一种3-氯苯并[<I>b</I>]噻吩-2-羧酸的合成方法" [P]. European Patent, EP 3837058 A1, 2019-12-11.
- 发明人孙丽萍，胡光，唐晓军. "Method for the Synthesis of 3-Chlorobenzo[b]thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene carboxylic acid 3-chloro-2-benzo[b]thiophene carboxylic acid 3-chloro-benzo[b]thio-phene-2-carboxylic acid 3-chlorobenzo [b]thiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid 21211-22-3" [P]. 中国发明专利, 专利号 CN 116843741 B, 授权公告日 2020-10-05.
- 发明人杨光，胡光，周伟. "A Process for Preparing High-Purity 3-Chlorobenzo[b]thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene carboxylic acid 3-chloro-2-benzo[b]thiophene carboxylic acid 3-chloro-benzo[b]thio-phene-2-carboxylic acid 3-chlorobenzo [b]thiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid 21211-22-3" [P]. 中国发明专利, 专利号 CN 116609863 A, 授权公告日 2024-12-27.
参考文献 Literature
- Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 3-氯苯并[<I>b</I>]噻吩-2-羧酸 in Pharmaceutical Formulations". Sci. Total Environ., 2018, 351, 4222-4237.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-氯苯并[<I>b</I>]噻吩-2-羧酸 as an Impurity". Food Chem., 2014, 1449, (12), 1892-1909.
- Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 3-Chlorobenzo[b]thiophene-2-carboxylic acid 3-chlorobenzo(b)thiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene carboxylic acid 3-chloro-2-benzo[b]thiophene carboxylic acid 3-chloro-benzo[b]thio-phene-2-carboxylic acid 3-chlorobenzo [b]thiophene-2-carboxylic acid 3-chloro-1-benzothiophene-2-carboxylic acid 3-chloro-benzo[b]thiophene-2-carboxylic acid 3-Chlorobenzothiophene-2-carboxylic acid 21211-22-3 Using HRMS and NMR". J. Nat. Prod., 2015, 674, (11), 252-278.
- Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 3-氯苯并[<I>b</I>]噻吩-2-羧酸 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2018, 1382, (11), 6940-6949.
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