3-氨基-2-噻吩甲酸甲酯 CAS 22288-78-4

Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4

纯度 97%+现货药物标准品
CAS 号22288-78-4
分子式C6H11NO2S
分子量161.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-氨基-2-噻吩甲酸甲酯 Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4 CAS 22288-78-4 结构式 Chemical Structure

产品介绍 Description

CAS 22288-78-4 对应的3-氨基-2-噻吩甲酸甲酯（Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4）为 CATO 佳途药物标准品产品线成员。分子式 C6H11NO2S，分子量 161.22。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，3-氨基-2-噻吩甲酸甲酯的分子量为161.22 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 22288-78-4 对应的化合物3-氨基-2-噻吩甲酸甲酯（英文标识 Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminoth

应用场景：3-氨基-2-噻吩甲酸甲酯（Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methy

理化性质 Physical & Chemical Properties

中文名称3-氨基-2-噻吩甲酸甲酯
分子式C6H11NO2S
分子量161.22 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1963年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. 发明人钱学锋，张德明，唐晓军. "一种3-氨基-2-噻吩甲酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 110477754 A, 授权公告日 2019-10-12.
  2. 发明人林芳，罗永刚，王建平. "Method for the Synthesis of Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4" [P]. 中国发明专利, 专利号 CN 110389421 B, 授权公告日 2015-09-17.
  3. Schröder R, Yamamoto T, Anderson J P. "A Process for Preparing High-Purity Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4" [P]. US Patent, US 11543462 B2, 2018-02-23.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 3-氨基-2-噻吩甲酸甲酯 in Pharmaceutical Formulations". J. Sep. Sci., 2021, 2001, (4), 8431-8454.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-氨基-2-噻吩甲酸甲酯 as an Impurity". Rapid Commun. Mass Spectrom., 2010, 1376, (10), 4515-4539.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of Methyl 3-amino-2-thiophenecarboxylate methyl-3-amino-2-thiophene carboxylate 3-aminothiophen-2-carboxylic acid methyl ester methyl 3-aminothiophene-2-carboxylate methyl-3-amino-2-thiophene formate 3-aminothiophene-2-carboxylic acid methyl ester 3-amino-thiophene-2-carboxylic acid methyl ester 3-amino-2-thiophenecarboxylic acid methyl ester 3-amino-2-methoxycarbonylthiophene 3-aminothiophene-2-carboxylic acidmethyl ester methyl-3-aminothiophene-2-carboxylate methyl 3-amino-2-thiophene carboxylate methyl-3-amino-thiophene-2-carboxylate methyl-3-amino-2-thiophene-carboxylate 22288-78-4 Using HRMS and NMR". Anal. Methods, 2010, 2068, (6), 1103-1124.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 3-氨基-2-噻吩甲酸甲酯 Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2015, 745, (10), 9471-9479.

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