tert-Butyl N-(4-hydroxycyclohexyl)carbamate CAS 224309-64-2

(4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate

纯度 97%+现货药物标准品
CAS 号224309-64-2
分子式C11H21NO3
分子量215.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-Butyl N-(4-hydroxycyclohexyl)carbamate (4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate CAS 224309-64-2 结构式 Chemical Structure

产品介绍 Description

CAS 224309-64-2 对应的tert-Butyl N-(4-hydroxycyclohexyl)carbamate（(4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate）为 CATO 佳途药物标准品产品线成员。分子式 C11H21NO3，分子量 215.29。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 224309-64-2 对应的化合物tert-Butyl N-(4-hydroxycyclohexyl)carbamate（英文标识 (4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate），化学式 C11H21NO3，相对分子质量 215.29。 依据分子式为 C11H21NO3 的tert-Butyl N-(4-hydroxycyclohexyl)carbamate结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在红外光谱中会呈现特征性的官能团伸缩振动信号。分子量 215.29 g/mol

应用场景：针对化学分析用途，tert-Butyl N-(4-hydroxycyclohexyl)carbamate（(4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate）是具有明确定量溯源的认证级对照品。 推荐以tert-Butyl N-(4-hydroxycyclohexyl)carbamate配制标

理化性质 Physical & Chemical Properties

中文名称tert-Butyl N-(4-hydroxycyclohexyl)carbamate
分子式C11H21NO3
分子量215.29 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）2021年
含氮原子数1

相关专利 Related Patents

  1. 发明人韩伟，张德明，郑宇鹏. "一种tert-Butyl N-(4-hydroxycyclohexyl)carbamate的合成方法" [P]. 中国发明专利, 专利号 CN 117631828 B, 授权公告日 2015-10-01.
  2. 发明人王建平，高志强，黄志刚. "Method for the Synthesis of (4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate" [P]. 中国发明专利, 专利号 CN 113716176 B, 授权公告日 2024-05-12.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of tert-Butyl N-(4-hydroxycyclohexyl)carbamate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2016, 553, (11), 1837-1855.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-Butyl N-(4-hydroxycyclohexyl)carbamate as an Impurity". J. Chromatogr. A, 2017, 1384, 4600-4628.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of (4-Hydroxycyclohexyl)carbamic Acid tert-Butyl Ester 224309-64-2 4-(Boc-amino)cyclohexanol 4-(tert-Butoxycarbonylamino)cyclohexanol B4714 tert-Butyl (4-Hydroxycyclohexyl)carbamate Using HRMS and NMR". Anal. Methods, 2013, 474, (7), 1067-1092.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate tert-Butyl N-(4-hydroxycyclohexyl)carbamate Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2011, 1836, (9), 7163-7174.

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