C18 Dihydroceramide (d18:0/18:0) CAS 2304-80-5

C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5

纯度 97%+现货药物标准品
CAS 号2304-80-5
分子式C36H73NO3
分子量567.97 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

C18 Dihydroceramide (d18:0/18:0) C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5 CAS 2304-80-5 结构式 Chemical Structure

产品介绍 Description

C18 Dihydroceramide (d18:0/18:0)（C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5）是药物分析与质量控制领域常用的药物标准品，CAS 号 2304-80-5。分子式 C36H73NO3，分子量 567.97。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

C18 Dihydroceramide (d18:0/18:0)（分子式 C36H73NO3）的化学结构中包含酰胺类，羧酸类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP）影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 CAS编号 2304-80-5 对应的化合物C18 Dihydroceramide (d18:0/18:0)（英文标识 C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)he

应用场景：从实际应用出发，C18 Dihydroceramide (d18:0/18:0)（CAS 2304-80-5）在化学分析中作为关键的基准对照物质。 推荐以C18 Dihydroceramide (d18:0/18:0)配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于室温保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶

理化性质 Physical & Chemical Properties

中文名称C18 Dihydroceramide (d18:0/18:0)
分子式C36H73NO3
分子量567.97 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
含氮原子数1

相关专利 Related Patents

  1. 发明人韩伟，张德明，沈红梅. "一种C18 Dihydroceramide (d18:0/18:0)的合成方法" [P]. 中国发明专利, 专利号 CN 112075782 B, 授权公告日 2019-10-22.
  2. 发明人冯建国，赵玉洁，郑宇鹏. "Method for the Synthesis of C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5" [P]. 中国发明专利, 专利号 CN 109972418 B, 授权公告日 2021-11-06.
  3. 发明人罗永刚，陈志强，孙丽萍. "A Process for Preparing High-Purity C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5" [P]. 中国发明专利, 专利号 CN 116729051 B, 授权公告日 2025-11-20.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of C18 Dihydroceramide (d18:0/18:0) in Pharmaceutical Formulations". Environ. Sci. Technol., 2014, 252, (3), 6833-6848.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of C18 Dihydroceramide (d18:0/18:0) as an Impurity". Sci. Total Environ., 2012, 214, (9), 2989-3012.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of C04977SRJ5 8AD8CNQ956 2304-80-5 N-Stearoyl dihydrosphingosine UNII-8AD8CNQ956 Octadecanamide, N-((1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl)- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, D-erythro- Octadecanamide, N-(2-hydroxy-1-(hydroxymethyl)heptadecyl)-, (R-(R*,S*))- (2S,3R)-2-(Octadecanoylamino)octadecane-1,3-diol UNII-C04977SRJ5 Using HRMS and NMR". Chromatographia, 2023, 527, (11), 1186-1211.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate C18 Dihydroceramide (d18:0/18:0) Profile in Drug Substances According to ICH Guidelines". Talanta, 2015, 2276, (4), 4475-4497.

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