CAS 2378428-19-2

N-[(1S)-1-{[(1S)-5-amino-1-{[({[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]methyl}carbamoyl)methyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-amide

纯度 97%+现货药物标准品
CAS 号2378428-19-2
分子式C53H69N9O17
分子量1104.17 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-[(1S)-1-{[(1S)-5-amino-1-{[({[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]methyl}carbamoyl)methyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-amide CAS 2378428-19-2 结构式 Chemical Structure

产品介绍 Description

（英文名 N-[(1S)-1-{[(1S)-5-amino-1-{[({[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]methyl}carbamoyl)methyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-amide，CAS 2378428-19-2）属于药物标准品。分子式 C53H69N9O17，分子量 1104.17。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C53H69N9O17 的（N-(1S)-1-{(1S)-5-amino-1-{({(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-ylmethyl}carbamoyl)methylcarbamoyl}pentylcarbamoyl}-2-methylpropyl-1-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido-3,6,9,1

应用场景：（N- (1S)-1-{ (1S)-5-amino-1-{ ({ (5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo 11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹ tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl methyl}carbamoyl)methyl carbamoyl}pentyl carbamoyl}-2-methylpropyl -1- 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)

理化性质 Physical & Chemical Properties

中文名称
分子式C53H69N9O17
分子量1104.17 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）24.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1999年
含氮原子数9

相关专利 Related Patents

  1. 发明人沈红梅，冯建国，赵玉洁. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110972943 A, 授权公告日 2015-04-20.
  2. Mueller T C, Sørensen M, Jørgensen K. "Method for the Synthesis of N-[(1S)-1-{[(1S)-5-amino-1-{[({[(5S)-5-ethyl-5-hydroxy-6,10-dioxo-7,18,20-trioxa-11,24-diazahexacyclo[11.11.0.0²,¹¹.0⁴,⁹.0¹⁵,²³.0¹⁷,²¹]tetracosa-1(24),2,4(9),13,15,17(21),22-heptaen-14-yl]methyl}carbamoyl)methyl]carbamoyl}pentyl]carbamoyl}-2-methylpropyl]-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-amide" [P]. European Patent, EP 3855850 A1, 2023-01-13.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chromatographia, 2022, 2087, (4), 7109-7130.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chem., 2014, 1281, (9), 7035-7064.

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