N-乙酰基-2,3-脱氢-2-脱氧神经氨酸 CAS 24967-27-9

(2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en

纯度 97%+现货药物标准品
CAS 号24967-27-9
分子式C11H17NO8
分子量291.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N-乙酰基-2,3-脱氢-2-脱氧神经氨酸 (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en CAS 24967-27-9 结构式 Chemical Structure

产品介绍 Description

CAS 24967-27-9 对应的N-乙酰基-2,3-脱氢-2-脱氧神经氨酸（(2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en）为 CATO 佳途药物标准品产品线成员。分子式 C11H17NO8，分子量 291.25。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 24967-27-9 对应的化合物N-乙酰基-2,3-脱氢-2-脱氧神经氨酸（英文标识 (2R,3R,4S)-3-acetamido-4-hydroxy-2-(1R,2R)-1,2,3-trihydroxypropyl-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en），化学式 C11H17NO8，相对分子质量 291.25。 N-乙酰基-2,3-脱氢-2-脱氧神经氨酸（分子式 C11H17NO8）的化学结构中包含氨基酸衍生物，酰胺类，含羟基

应用场景：N-乙酰基-2,3-脱氢-2-脱氧神经氨酸（(2R,3R,4S)-3-acetamido-4-hydroxy-2- (1R,2R)-1,2,3-trihydroxypropyl -3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA

理化性质 Physical & Chemical Properties

中文名称N-乙酰基-2,3-脱氢-2-脱氧神经氨酸
分子式C11H17NO8
分子量291.25 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1964年
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，张德明，赵玉洁. "一种N-乙酰基-2,3-脱氢-2-脱氧神经氨酸的合成方法" [P]. 中国发明专利, 专利号 CN 111125783 B, 授权公告日 2018-01-08.
  2. 发明人杨光，朱建伟，韩伟. "Method for the Synthesis of (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en" [P]. 中国发明专利, 专利号 CN 115516864 A, 授权公告日 2025-09-03.
  3. 发明人高志强，罗永刚，周伟. "A Process for Preparing High-Purity (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en" [P]. 中国发明专利, 专利号 CN 115681770 A, 授权公告日 2019-01-10.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of N-乙酰基-2,3-脱氢-2-脱氧神经氨酸 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2016, 1682, (3), 9091-9116.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of N-乙酰基-2,3-脱氢-2-脱氧神经氨酸 as an Impurity". Sci. Total Environ., 2011, 1461, 7285-7312.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid 2-Deoxy-2,3-didehydro-D-N--acetylneuraminic acid 24967-27-9 6-((2R)-1,2,3-Trihydroxypropyl)(4S,5R,6R)-5-(acetylamino)-4-hydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid DANA Neu5Ac2en Using HRMS and NMR". Anal. Chem., 2023, 1433, (7), 9003-9032.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate N-乙酰基-2,3-脱氢-2-脱氧神经氨酸 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2025, 2385, (4), 3484-3507.

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