异丁酰基-<SC> L </SC>-肉碱 CAS 25518-49-4

25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin

纯度 97%+现货药物标准品
CAS 号25518-49-4
分子式C11H21NO4
分子量231.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

异丁酰基-<SC> L </SC>-肉碱 25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin CAS 25518-49-4 结构式 Chemical Structure

产品介绍 Description

CAS 25518-49-4 对应的异丁酰基-<SC> L </SC>-肉碱（25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin）为 CATO 佳途药物标准品产品线成员。分子式 C11H21NO4，分子量 231.29。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，异丁酰基-<SC> L </SC>-肉碱的分子量为231.29 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 异丁酰基-<SC> L </SC>-肉碱（25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin German Isobutyryl-carnitine Isobutyryl-L-carnitin

应用场景：在化学分析实验室中，异丁酰基-<SC> L </SC>-肉碱（CAS 25518-49-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以异丁酰基-<SC> L </SC>-肉碱配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后

理化性质 Physical & Chemical Properties

中文名称异丁酰基-<SC> L </SC>-肉碱
分子式C11H21NO4
分子量231.29 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1964年
含氮原子数1

相关专利 Related Patents

  1. 发明人杨光，李文辉，钱学锋. "一种异丁酰基-<SC> L </SC>-肉碱的合成方法" [P]. 中国发明专利, 专利号 CN 112223509 A, 授权公告日 2019-04-10.
  2. 发明人徐明华，马晓峰，高志强. "Method for the Synthesis of 25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin" [P]. 中国发明专利, 专利号 CN 117190582 B, 授权公告日 2023-03-21.
  3. 发明人何建平，冯建国，黄志刚. "A Process for Preparing High-Purity 25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin" [P]. 中国发明专利, 专利号 CN 109483807 A, 授权公告日 2022-02-18.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 异丁酰基-<SC> L </SC>-肉碱 in Pharmaceutical Formulations". J. Chromatogr. A, 2017, 1268, 2504-2524.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 异丁酰基-<SC> L </SC>-肉碱 as an Impurity". Anal. Methods, 2019, 752, (3), 3890-3908.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 25518-49-4 Isobutyryl-1-carnitine Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isobutyrate, L- (S)-3-Carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt 1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-, inner salt, (R)- (9CI) BRN 4138517 Iso-butyryl-L(-)-carnitin [German] Isobutyryl-carnitine Isobutyryl-L-carnitine Iso-butyryl-L(-)-carnitin Using HRMS and NMR". Environ. Sci. Technol., 2022, 1779, (9), 751-770.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 异丁酰基-<SC> L </SC>-肉碱 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2016, 196, 8999-9005.

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