2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷 CAS 2554-06-5
2554-06-5 3NT606T1VK 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- 2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl- EINECS 219-863-1 2,4,6,8-Tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane S-Tetramethyltetravinylcyclotetrasiloxane Tetravinyltetramethylcyclotetrasiloxane TM-TVCS UNII-3NT606T1VK EC 219-863-1
| CAS 号 | 2554-06-5 |
| 分子式 | C12H24O4Si4 |
| 分子量 | 344.66 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷（2554-06-5 3NT606T1VK 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- 2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl- EINECS 219-863-1 2,4,6,8-Tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane S-Tetramethyltetravinylcyclotetrasiloxane Tetravinyltetramethylcyclotetrasiloxane TM-TVCS UNII-3NT606T1VK EC 219-863-1，CAS 号 2554-06-5）是 CATO 佳途自主生产的药物标准品，分子式 C12H24O4Si4，分子量 344.66。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷（2554-06-5 3NT606T1VK 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- 2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl- EINECS 219-863-1 2,4,6,8-Tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane S-Tetramethyltetravinylcyclotetrasiloxane Tetravi
应用场景：在化学分析实验室中，2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷（CAS 2554-06-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于阴凉处（≤25°C）保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶
理化性质 Physical & Chemical Properties
| 中文名称 | 2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷 |
| 分子式 | C12H24O4Si4 |
| 分子量 | 344.66 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，密封防潮 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1957年 |
相关专利 Related Patents
- Brown S R, Kumar R, Park J H. "一种2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷的合成方法" [P]. US Patent, US 11595147 B2, 2023-03-20.
- 发明人王建平，朱建伟，郭海燕. "Method for the Synthesis of 2554-06-5 3NT606T1VK 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- 2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl- EINECS 219-863-1 2,4,6,8-Tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane S-Tetramethyltetravinylcyclotetrasiloxane Tetravinyltetramethylcyclotetrasiloxane TM-TVCS UNII-3NT606T1VK EC 219-863-1" [P]. 中国发明专利, 专利号 CN 116440102 B, 授权公告日 2020-09-17.
- 发明人郭海燕，沈红梅，孙丽萍. "A Process for Preparing High-Purity 2554-06-5 3NT606T1VK 1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetraethenyl-2,4,6,8-tetramethyl- 2,4,6,8-Tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane Cyclotetrasiloxane, 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl- EINECS 219-863-1 2,4,6,8-Tetraethenyl-2,4,6,8-tetramethylcyclotetrasiloxane S-Tetramethyltetravinylcyclotetrasiloxane Tetravinyltetramethylcyclotetrasiloxane TM-TVCS UNII-3NT606T1VK EC 219-863-1" [P]. 中国发明专利, 专利号 CN 111360524 A, 授权公告日 2017-02-01.
参考文献 Literature
- Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷 in Pharmaceutical Formulations". Environ. Sci. Technol., 2012, 981, 1231-1252.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2,4,6,8-四甲基-2,4,6,8-四乙烯基环四硅氧烷 as an Impurity". J. Sep. Sci., 2013, 199, (4), 1462-1466.
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