1-(2-Chloroethyl)azepane hydrochloride CAS 26487-67-2

26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513

纯度 97%+现货药物标准品
CAS 号26487-67-2
分子式C8H16ClN HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(2-Chloroethyl)azepane hydrochloride 26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513 CAS 26487-67-2 结构式 Chemical Structure

产品介绍 Description

1-(2-Chloroethyl)azepane hydrochloride（26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513，CAS 号 26487-67-2）是 CATO 佳途自主生产的药物标准品，分子式 C8H16ClN HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

1-(2-Chloroethyl)azepane hydrochloride的产生途径与其化学式中含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 26487-67-2 对应的化合物1-(2-Chloroethyl)azepane hydrochloride（英文标识 26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513），化学式 C8H16ClN HCl，相对分子质量 198.13。

应用场景：针对化学分析用途，1-(2-Chloroethyl)azepane hydrochloride（26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-

理化性质 Physical & Chemical Properties

中文名称1-(2-Chloroethyl)azepane hydrochloride
分子式C8H16ClN HCl
分子量198.13 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.0
CAS登记年份（估）1964年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人冯建国，郑宇鹏，郭海燕. "一种1-(2-Chloroethyl)azepane hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 112896674 A, 授权公告日 2016-07-01.
  2. 发明人刘建华，罗永刚，高志强. "Method for the Synthesis of 26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513" [P]. 中国发明专利, 专利号 CN 113161745 A, 授权公告日 2019-08-03.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(2-Chloroethyl)azepane hydrochloride in Pharmaceutical Formulations". Chemosphere, 2013, 963, (6), 4376-4380.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(2-Chloroethyl)azepane hydrochloride as an Impurity". Environ. Sci. Technol., 2019, 467, 5453-5462.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 26487-67-2 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (8CI)(9CI) 1H-Azepine, hexahydro-1-(2-chloroethyl)-, hydrochloride N-(2-Chloroethyl)perhydroazepine hydrochloride 1-(2-Chloroethyl)-hexahydro-1H-azepine hydrochloride EINECS 247-733-4 2-(Hexamethyleneimino)ethyl chloride hydrochloride NSC 74513 Using HRMS and NMR". Anal. Chim. Acta, 2020, 481, 9031-9042.

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