三(羟甲基)膦 CAS 2767-80-8

2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ

纯度 97%+现货药物标准品
CAS 号2767-80-8
分子式C3H9O3P
分子量124.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

三(羟甲基)膦 2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ CAS 2767-80-8 结构式 Chemical Structure

产品介绍 Description

三(羟甲基)膦（2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ）是药物分析与质量控制领域常用的药物标准品，CAS 号 2767-80-8。分子式 C3H9O3P，分子量 124.08。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在质量保证方面，三(羟甲基)膦的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 2767-80-8 对应的化合物三(羟甲基)膦（英文标识 2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ），化学式 C3H9O3P，相对分子质量 124.08。 依

应用场景：三(羟甲基)膦（2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ，CAS 2767

理化性质 Physical & Chemical Properties

中文名称三(羟甲基)膦
分子式C3H9O3P
分子量124.08 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-0.5
CAS登记年份（估）1957年

相关专利 Related Patents

  1. 发明人徐明华，何建平，郭海燕. "一种三(羟甲基)膦的合成方法" [P]. 中国发明专利, 专利号 CN 114302801 A, 授权公告日 2024-07-04.
  2. Johansson L, Jørgensen K, Lefèvre J P. "Method for the Synthesis of 2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ" [P]. European Patent, EP 3415080 A1, 2024-02-12.
  3. Schröder R, Mueller T, Davis P L. "A Process for Preparing High-Purity 2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ" [P]. US Patent, US 11631159 B2, 2018-05-19.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 三(羟甲基)膦 in Pharmaceutical Formulations". Chemosphere, 2021, 1546, 298-304.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 三(羟甲基)膦 as an Impurity". J. Sep. Sci., 2017, 215, (10), 7951-7956.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 2767-80-8 Y6TG7WF7OQ Tris(hydroxymethyl)phosphine Methanol, phosphinidynetri- (7CI,8CI) Methanol, phosphinidynetris- Phosphinidynetrimethanol Methanol, 1,1',1''-phosphinidynetris- EINECS 220-445-6 Phosphinidynetrismethanol Trimethylolphosphine Tris(methanol)phosphine UNII-Y6TG7WF7OQ Using HRMS and NMR". Anal. Methods, 2011, 1332, (12), 6147-6176.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 三(羟甲基)膦 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2011, 1134, 3544-3550.

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