三苯基溴化膦异戊酯 CAS 28322-40-9

28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide

纯度 97%+现货药物标准品
CAS 号28322-40-9
分子式C23H44P Br
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

三苯基溴化膦异戊酯 28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide CAS 28322-40-9 结构式 Chemical Structure

产品介绍 Description

三苯基溴化膦异戊酯（28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide，CAS 号 28322-40-9）是 CATO 佳途自主生产的药物标准品，分子式 C23H44P Br。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

三苯基溴化膦异戊酯（28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide），CAS注册编号 28322-40-9，化学分子式为 C23H44P Br，分子量 431.48 g/mol。 受分子结构中有机磷，含溴取代的影响，三苯基溴化膦异戊酯表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味）。其固体形态的物理化学属性——包括431.48 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。因分子内存在卤素取代基（F/Cl/Br/I），该化合物在质谱分析中呈现特征性的同位素分布模式，可作为定性确认的重要依据。 在定量分析中，可作为校准标准

应用场景：三苯基溴化膦异戊酯（28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以三苯基溴化膦异戊酯配制标准系列工作溶液，用于

理化性质 Physical & Chemical Properties

中文名称三苯基溴化膦异戊酯
分子式C23H44P Br
分子量431.48 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）1965年
卤素含量Br取代

相关专利 Related Patents

  1. 发明人王建平，唐晓军，冯建国. "一种三苯基溴化膦异戊酯的合成方法" [P]. 中国发明专利, 专利号 CN 114057937 A, 授权公告日 2023-06-05.
  2. Davis P L, Stevens L M, Williams B T. "Method for the Synthesis of 28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide" [P]. US Patent, US 9204083 B2, 2017-07-26.
  3. 发明人林芳，罗永刚，胡光. "A Process for Preparing High-Purity 28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide" [P]. 中国发明专利, 专利号 CN 109143746 B, 授权公告日 2017-02-02.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 三苯基溴化膦异戊酯 in Pharmaceutical Formulations". Food Chem., 2018, 817, 6756-6761.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 三苯基溴化膦异戊酯 as an Impurity". J. Chromatogr. A, 2012, 792, (4), 1426-1453.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 28322-40-9 Isoamyltriphenylphosphonium bromide iso-amyl triphenylphosphonium bromide isoamyl triphenyl phosphonium bromide isoamyl triphenylphosphonium bromide isopentyl triphenylphosphonium bromide isopentyltriphenylphosphonium bromide Using HRMS and NMR". Talanta, 2022, 1757, 430-455.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 三苯基溴化膦异戊酯 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2014, 133, (10), 792-817.

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