CAS 28489-47-6

2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE 6-FLUORO-2-METHYL-3-PYRIDINAMINE 6-FLUORO-2-METHYL-3-PYRIDYLAMINE 6-FLUORO-2-METHYLPYRIDIN-3-AMINE 6-FLUORO-2-METHYLPYRIDIN-3-YLAMINE TF10681

纯度 97%+现货药物标准品
CAS 号28489-47-6
分子式2*C6H7FN2
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE 6-FLUORO-2-METHYL-3-PYRIDINAMINE 6-FLUORO-2-METHYL-3-PYRIDYLAMINE 6-FLUORO-2-METHYLPYRIDIN-3-AMINE 6-FLUORO-2-METHYLPYRIDIN-3-YLAMINE TF10681 CAS 28489-47-6 结构式 Chemical Structure

产品介绍 Description

（英文名 2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE 6-FLUORO-2-METHYL-3-PYRIDINAMINE 6-FLUORO-2-METHYL-3-PYRIDYLAMINE 6-FLUORO-2-METHYLPYRIDIN-3-AMINE 6-FLUORO-2-METHYLPYRIDIN-3-YLAMINE TF10681，CAS 28489-47-6）属于药物标准品。分子式 2*C6H7FN2。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

受分子结构中含氰基，含氟取代的影响，表现为类白色至淡黄色液体。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括126.13 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。因分子内存在卤素取代基（F/Cl/Br/I），该化合物在质谱分析中呈现特征性的同位素分布模式，可作为定性确认的重要依据。 （2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE

应用场景：（2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-ME

理化性质 Physical & Chemical Properties

中文名称
分子式2*C6H7FN2
分子量126.13 g/mol
外观形态类白色至淡黄色液体。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1965年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. Patel M V, Park J H, Fischer A B. "一种的合成方法" [P]. US Patent, US 11141179 B2, 2017-09-27.
  2. 发明人陈志强，郑宇鹏，张德明. "Method for the Synthesis of 2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE 6-FLUORO-2-METHYL-3-PYRIDINAMINE 6-FLUORO-2-METHYL-3-PYRIDYLAMINE 6-FLUORO-2-METHYLPYRIDIN-3-AMINE 6-FLUORO-2-METHYLPYRIDIN-3-YLAMINE TF10681" [P]. 中国发明专利, 专利号 CN 117009932 B, 授权公告日 2020-08-10.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Food Chem., 2018, 1607, (4), 6834-6854.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Environ. Sci. Technol., 2020, 2316, 3653-3662.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2-FLUORO-5-AMINO-6-PICOLINE 2-METHYL-3-AMINO-6-FLUOROPYRIDINE 2-PICOLINE, 3-AMINO-6-FLUORO- 28489-47-6 3-AMINO-6-FLUORO-2-METHYLPYRIDINE 3-AMINO-6-FLUORO-2-PICOLINE 3-AMINO-6-FLUOROPICOLINE 3-PYRIDINAMINE, 6-FLUORO-2-METHYL- 5-AMINO-2-FLUORO-6-METHYLPYRIDINE 5-AMINO-2-FLUORO-6-PICOLINE 5-AMINO-6-METHYL-2-FLUOROPYRIDINE 6-FLUORO-2-METHYL-3-PYRIDINAMINE 6-FLUORO-2-METHYL-3-PYRIDYLAMINE 6-FLUORO-2-METHYLPYRIDIN-3-AMINE 6-FLUORO-2-METHYLPYRIDIN-3-YLAMINE TF10681 Using HRMS and NMR". Sci. Total Environ., 2012, 1669, 5474-5483.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2014, 511, (1), 9487-9512.

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