(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺 CAS 286454-86-2

(S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579

纯度 97%+现货药物标准品
CAS 号286454-86-2
分子式C18H36NP
分子量297.46 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺 (S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579 CAS 286454-86-2 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺（(S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579，CAS 286454-86-2），分子式 C18H36NP，分子量 297.46。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺的产生途径与其化学式中有机磷密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C18H36NP 的(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺（(S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579），其CAS登记号是 286454-86-2，分子量为 297.46 g/mol。 (<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺（分子式 C18

应用场景：针对化学分析用途，(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺（(S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺
分子式C18H36NP
分子量297.46 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.5
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. Schröder R, O'Brien P Q, Roberts E F. "一种(<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺的合成方法" [P]. US Patent, US 9705939 B2, 2022-02-20.
  2. 发明人杨光，冯建国，林芳. "Method for the Synthesis of (S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579" [P]. 中国发明专利, 专利号 CN 108982509 A, 授权公告日 2016-05-08.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺 in Pharmaceutical Formulations". Molecules, 2022, 315, 7105-7125.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺 as an Impurity". Anal. Methods, 2023, 2147, (9), 1576-1587.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (S)-1-(Diphenylphosphino)-2-amino-3,3-dimethylbutane 286454-86-2 (S)-1-(DIPHENYLPHOSPHINO)-2-AMINO-3,3-DIMETHYLBUTANE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYL-2-BUTYLAMINE;(S)-1-(DIPHENYLPHOSPHINO)-3,3-DIMETHYLBUTAN-2-AMINE;(S)-2-AMINO-1-DIPHENYLPHOSPHINO-3,3-DIMETHYLBUTANE SC11579 Using HRMS and NMR". Chromatographia, 2024, 1319, (9), 9835-9853.
  4. Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate (<I>S</I>)-1-(二苯基膦基)-3,3-二甲基丁烷-2-胺 Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2023, 272, 5116-5124.

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