3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester CAS 287944-16-5

2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313

纯度 97%+现货药物标准品
CAS 号287944-16-5
分子式C11H19BO3
分子量210.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester 2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313 CAS 287944-16-5 结构式 Chemical Structure

产品介绍 Description

CAS 287944-16-5 对应的3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester（2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313）为 CATO 佳途药物标准品产品线成员。分子式 C11H19BO3，分子量 210.08。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

从化学结构特征来看，3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester的分子骨架中包含羧酸类，含羟基，含醚键。该化合物的不饱和度为2.5，表明结构中存在约2个环或双键等价单元。分子量为210.08 g/mol，属于中等分子量化合物。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 CAS编号 287944-16-5 对应的化合物3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester（英文标识 2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313），化学式 C

应用场景：在化学分析实验室中，3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester（CAS 287944-16-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用乙腈配制，于阴凉处（≤25°C）保存，密封

理化性质 Physical & Chemical Properties

中文名称3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester
分子式C11H19BO3
分子量210.08 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.5
CAS登记年份（估）2025年

相关专利 Related Patents

  1. Anderson J P, Lee S K, O'Brien P Q. "一种3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester的合成方法" [P]. US Patent, US 11823901 B2, 2021-07-11.
  2. Yamamoto T, Roberts E F, Mueller T. "Method for the Synthesis of 2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313" [P]. US Patent, US 11331223 B2, 2017-03-28.
  3. 发明人钱学锋，张德明，沈红梅. "A Process for Preparing High-Purity 2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313" [P]. 中国发明专利, 专利号 CN 116022360 A, 授权公告日 2023-01-12.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester in Pharmaceutical Formulations". J. Nat. Prod., 2022, 1283, (7), 9640-9655.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester as an Impurity". Chromatographia, 2020, 1287, 428-441.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 2-(3,6-DIHYDRO-2H-PYRAN-4-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 287944-16-5 3,6-DIHYDRO-2H-PYRAN-4-BORONIC ACID PINACOL ESTER 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDRO-2H-PYRAN BC000313 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2010, 1666, (7), 5772-5788.
  4. Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate 3,6-Dihydro-2<I>H</I>-pyran-4-boronic acid pinacol ester Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2017, 1717, 9264-9287.

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