异氰酰乙酸乙酯 CAS 2949-22-6
2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276
| CAS 号 | 2949-22-6 |
| 分子式 | C5H7NO3 |
| 分子量 | 129.11 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
异氰酰乙酸乙酯（2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276）是药物分析与质量控制领域常用的药物标准品，CAS 号 2949-22-6。分子式 C5H7NO3，分子量 129.11。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 化学式为 C5H7NO3 的异氰酰乙酸乙酯（2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276），其CAS登记号是 2949-22-6，分子量为 129.11 g/mol。 异氰酰乙酸乙酯（C5H7NO3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决
应用场景：针对化学分析用途，异氰酰乙酸乙酯（2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate
理化性质 Physical & Chemical Properties
| 中文名称 | 异氰酰乙酸乙酯 |
| 分子式 | C5H7NO3 |
| 分子量 | 129.11 g/mol |
| 外观形态 | 白色至淡黄色液体。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO、水 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- Jørgensen K, Schröder R, Rossi M. "一种异氰酰乙酸乙酯的合成方法" [P]. European Patent, EP 3589924 A1, 2022-10-26.
- 发明人林芳，胡光，周伟. "Method for the Synthesis of 2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276" [P]. 中国发明专利, 专利号 CN 115919386 B, 授权公告日 2020-08-01.
- 发明人孙丽萍，杨光，朱建伟. "A Process for Preparing High-Purity 2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276" [P]. 中国发明专利, 专利号 CN 113265069 B, 授权公告日 2015-01-10.
参考文献 Literature
- Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 异氰酰乙酸乙酯 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2025, 731, 2338-2354.
- Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 异氰酰乙酸乙酯 as an Impurity". Rapid Commun. Mass Spectrom., 2022, 730, 6030-6047.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2949-22-6 Acetic acid, isocyanato-, ethyl ester Ethyl isocyanatoacetate Acetic acid, 2-isocyanato-, ethyl ester AI3-52377 Carbethoxymethyl isocyanate EINECS 220-967-4 Ethoxycarbonylmethyl isocyanate Ethyl glycolate isocyanate Isocyanatoacetic acid ethyl ester Isocyanatoethyl acetate NSC 56429 NSC 6276 Using HRMS and NMR". J. Agric. Food Chem., 2025, 449, (9), 2924-2943.
- O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 异氰酰乙酸乙酯 Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2016, 152, (7), 5898-5913.
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