03:0 Coenzyme A CAS 317-66-8

3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA

纯度 97%+现货药物标准品
CAS 号317-66-8
分子式C24H37N7O17P3S 3*Na
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

03:0 Coenzyme A 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA CAS 317-66-8 结构式 Chemical Structure

产品介绍 Description

03:0 Coenzyme A（3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA）是药物分析与质量控制领域常用的药物标准品，CAS 号 317-66-8。分子式 C24H37N7O17P3S 3*Na。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

CAS编号 317-66-8 对应的化合物03:0 Coenzyme A（英文标识 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-(3-oxo-3-{2-(propanoylsulfanyl)ethylamino}propyl)aminobutyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA），化学式 C24H37N7O17P3S 3Na，相对分子质量 843.56。 03:0 Coenzyme A（C24H37N7O17P3S 3Na）含有黄酮骨架，酰胺类，含砜基，含磷酸酯基，含羟基，含醚键。具有较强的

应用场景：03:0 Coenzyme A（3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4- (3-oxo-3-{ 2-(propanoylsulfanyl)ethyl amino}propyl)amino butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl

理化性质 Physical & Chemical Properties

中文名称03:0 Coenzyme A
分子式C24H37N7O17P3S 3*Na
分子量843.56 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
含氮原子数7
含硫原子数1

相关专利 Related Patents

  1. Anderson J P, Kumar R, Fischer A B. "一种03:0 Coenzyme A的合成方法" [P]. US Patent, US 9813371 B2, 2015-09-26.
  2. O'Brien P Q, Kumar R, Williams B T. "Method for the Synthesis of 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA" [P]. US Patent, US 10597034 B2, 2022-07-12.
  3. 发明人朱建伟，李文辉，冯建国. "A Process for Preparing High-Purity 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA" [P]. 中国发明专利, 专利号 CN 109346667 A, 授权公告日 2016-07-13.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 03:0 Coenzyme A in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2021, 1320, 4557-4561.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 03:0 Coenzyme A as an Impurity". Anal. Chim. Acta, 2013, 277, (5), 4881-4910.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate) 317-66-8 CHEBI:15539 Propanoyl-CoA Propionyl coenzyme A Propionyl-coenzyme A S-Propionyl-coenzym-A S-Propionylcoenzyme A S-propanoyl-CoA S-propanoyl-coenzyme A propanoyl-coenzyme A propionyl-CoA Using HRMS and NMR". Sci. Total Environ., 2019, 955, 9558-9567.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 03:0 Coenzyme A Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2015, 2463, (11), 5610-5639.

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