3-溴氰苄 CAS 31938-07-5

2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile

纯度 97%+现货药物标准品
CAS 号31938-07-5
分子式C8H12BrN
分子量202.09 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-溴氰苄 2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile CAS 31938-07-5 结构式 Chemical Structure

产品介绍 Description

CAS 31938-07-5 对应的3-溴氰苄（2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile）为 CATO 佳途药物标准品产品线成员。分子式 C8H12BrN，分子量 202.09。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C8H12BrN 的3-溴氰苄（2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile），其CAS登记号是 31938-07-5，分子量为 202.09 g/mol。 3-溴氰苄（分子式 C8H12BrN）的化学结构中包含含氰基，含溴取代。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据

应用场景：3-溴氰苄（2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile，CAS 31938-07-5）的标准化应用场景涵盖化学分析等多个专业

理化性质 Physical & Chemical Properties

中文名称3-溴氰苄
分子式C8H12BrN
分子量202.09 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1966年
卤素含量Br取代
含氮原子数1

相关专利 Related Patents

  1. 发明人杨光，高志强，李文辉. "一种3-溴氰苄的合成方法" [P]. 中国发明专利, 专利号 CN 114055799 A, 授权公告日 2015-08-07.
  2. 发明人朱建伟，高志强，郭海燕. "Method for the Synthesis of 2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile" [P]. 中国发明专利, 专利号 CN 115938147 A, 授权公告日 2017-10-27.
  3. 发明人何建平，郑宇鹏，郭海燕. "A Process for Preparing High-Purity 2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile" [P]. 中国发明专利, 专利号 CN 110035806 B, 授权公告日 2015-03-02.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 3-溴氰苄 in Pharmaceutical Formulations". Anal. Chem., 2018, 1638, (4), 1279-1307.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-溴氰苄 as an Impurity". Talanta, 2017, 2358, (12), 1740-1758.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2-(3-BROMOPHENYL)ACETONITRILE 2-(3-BROMOPHENYL)ETHANENITRILE 3-BROMOBENZENEACETONITRILE 3-BROMOBENZYL CYANIDE 3-BROMOPHENYLACETONITRILE 31938-07-5 BENZENEACETONITRILE, 3-BROMO- M-BROMOBENZYL CYANIDE M-BROMOPHENYLACETONITRILE PF10722 m-fluorophenylacetonitrile Using HRMS and NMR". Biomed. Chromatogr., 2020, 1684, 3093-3103.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 3-溴氰苄 Profile in Drug Substances According to ICH Guidelines". Molecules, 2024, 620, (12), 9040-9059.

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