2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one CAS 351005-68-0

2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号351005-68-0
分子式C17H16N2OS2
分子量328.45 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one CAS 351005-68-0 结构式 Chemical Structure

产品介绍 Description

2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one（英文名 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one，CAS 351005-68-0）属于药物标准品。分子式 C17H16N2OS2，分子量 328.45。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C17H16N2OS2 的2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one（2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one），其CAS登记号是 351005-68-0，分子量为 328.45 g/mol。 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta4,5thieno2,3-dpyrimidin-4-one（分子式 C17H16N2OS2）的化学结构中包含甾体骨架，酰胺类，含硫有机，含羟基，含醚键。在反相色谱体系中，其保留行为主要受其较高的疏水性（logP

应用场景：针对化学分析用途，2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta 4,5 thieno 2,3-d pyrimidin-4-one（2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta 4,5 thieno 2,3-d pyrimidin-4-one）是具有明确定量溯源的认证级对照品。 推荐以2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta 4,5 thieno 2,3-d

理化性质 Physical & Chemical Properties

中文名称2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one
分子式C17H16N2OS2
分子量328.45 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2
含硫原子数2

相关专利 Related Patents

  1. Kumar R, Yamamoto T, Hughes D C. "一种2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one的合成方法" [P]. US Patent, US 9398453 B2, 2019-08-11.
  2. 发明人钱学锋，赵玉洁，陈志强. "Method for the Synthesis of 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 115469650 A, 授权公告日 2019-11-20.
  3. 发明人孙丽萍，何建平，冯建国. "A Process for Preparing High-Purity 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 109385434 B, 授权公告日 2025-12-11.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one in Pharmaceutical Formulations". Anal. Chim. Acta, 2015, 1450, (11), 9729-9732.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as an Impurity". J. Sep. Sci., 2012, 2460, 8085-8098.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 2-mercapto-3-(2-phenylethyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2014, 181, 3704-3719.

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