5-Bromo-3-methoxypicolinonitrile CAS 36057-46-2

36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122

纯度 97%+现货药物标准品
CAS 号36057-46-2
分子式C7H11BrN2O
分子量219.08 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-Bromo-3-methoxypicolinonitrile 36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122 CAS 36057-46-2 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的5-Bromo-3-methoxypicolinonitrile（36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122）为药物标准品，CAS 登记号 36057-46-2，分子式 C7H11BrN2O，分子量 219.08。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

5-Bromo-3-methoxypicolinonitrile的产生途径与其化学式中酰胺类，含羟基，含醚键，含溴取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C7H11BrN2O 的5-Bromo-3-methoxypicolinonitrile（36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122），其CAS登记号是 36057-46-2，分子量为 219.08 g/mol。 依据分子式为 C7H11BrN2O 的5-Bromo-3-methoxypicolinonitrile结构特征，其分子内含酰胺类，含羟基，含醚键，含溴取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 219.08 g/mol 这

应用场景：针对化学分析用途，5-Bromo-3-methoxypicolinonitrile（36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122）是具有明确定量溯源的认证级对照品。 推荐以5-Bromo-3-methoxypicolinonitrile配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称5-Bromo-3-methoxypicolinonitrile
分子式C7H11BrN2O
分子量219.08 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1967年
卤素含量Br取代
含氮原子数2

相关专利 Related Patents

  1. Jørgensen K, Johansson L, Kowalski A. "一种5-Bromo-3-methoxypicolinonitrile的合成方法" [P]. European Patent, EP 3308086 A1, 2016-05-27.
  2. Nielsen H, Lefèvre J P, Mueller T C. "Method for the Synthesis of 36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122" [P]. European Patent, EP 3649383 A1, 2021-01-02.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 5-Bromo-3-methoxypicolinonitrile in Pharmaceutical Formulations". J. Nat. Prod., 2015, 1790, (9), 9868-9883.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-Bromo-3-methoxypicolinonitrile as an Impurity". J. Pharm. Biomed. Anal., 2019, 989, (7), 5661-5671.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 36057-46-2 5-BROMO-2-CYANO-3-METHOXYPYRIDINE 5-BROMO-3-METHOXY-2-PYRIDINECARBONITRILE 5-BROMO-3-METHOXY-PYRIDINE 2-CARBONITRILE 5-BROMO-3-METHOXYPICOLINONITRILE ABBYPHARMA AP-10-5699 BC004122 Using HRMS and NMR". J. Agric. Food Chem., 2024, 2466, 689-717.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 5-Bromo-3-methoxypicolinonitrile Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2022, 1627, 301-315.

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