双环己酮草酰二腙 CAS 370-81-0

5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO

纯度 97%+现货药物标准品
CAS 号370-81-0
分子式C14H22N4O2
分子量278.35 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

双环己酮草酰二腙 5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO CAS 370-81-0 结构式 Chemical Structure

产品介绍 Description

双环己酮草酰二腙（5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO，CAS 号 370-81-0）是 CATO 佳途自主生产的药物标准品，分子式 C14H22N4O2，分子量 278.35。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 370-81-0 对应的化合物双环己酮草酰二腙（英文标识 5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, b

应用场景：双环己酮草酰二腙（5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone

理化性质 Physical & Chemical Properties

中文名称双环己酮草酰二腙
分子式C14H22N4O2
分子量278.35 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1957年
含氮原子数4

相关专利 Related Patents

  1. Nowak P, Schröder R, Jørgensen K. "一种双环己酮草酰二腙的合成方法" [P]. European Patent, EP 3921417 A1, 2018-01-05.
  2. 发明人冯建国，马晓峰，唐晓军. "Method for the Synthesis of 5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO" [P]. 中国发明专利, 专利号 CN 109971416 A, 授权公告日 2017-02-18.
  3. 发明人沈红梅，郑宇鹏，韩伟. "A Process for Preparing High-Purity 5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO" [P]. 中国发明专利, 专利号 CN 110378202 A, 授权公告日 2018-05-12.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 双环己酮草酰二腙 in Pharmaceutical Formulations". Food Chem., 2022, 533, (10), 188-206.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 双环己酮草酰二腙 as an Impurity". J. Chromatogr. A, 2016, 1625, (5), 135-156.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 5N16U7E0AO 370-81-0 Cuprizone Ethanedioic acid, bis(cyclohexylidenehydrazide) Oxalic acid, bis(cyclohexylidenehydrazide) N,N-Oxalylbis(cyclohexanone hydrazone) Ethanedioic acid, 1,2-bis(2-cyclohexylidenehydrazide) 4-07-00-00025 (Beilstein Handbook Reference) Biscyclohexanone oxaldihydrazone Biscyclohexanone oxalyldihydrazone BRN 2388004 Cuprizane EINECS 206-729-2 Ethanedioic acid, bis(cyclohexylidene hydrazide) NSC 4283 Oxalic acid bis(cyclohexylidenehydrazide) UNII-5N16U7E0AO Using HRMS and NMR". J. Pharm. Biomed. Anal., 2012, 940, 1609-1627.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 双环己酮草酰二腙 Profile in Drug Substances According to ICH Guidelines". Talanta, 2017, 200, (6), 8095-8101.

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