1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid CAS 3719-45-7

3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA

纯度 97%+现货药物标准品
CAS 号3719-45-7
分子式C7H7NO3
分子量153.14 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid 3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA CAS 3719-45-7 结构式 Chemical Structure

产品介绍 Description

CAS 3719-45-7 对应的1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid（3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA）为 CATO 佳途药物标准品产品线成员。分子式 C7H7NO3，分子量 153.14。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid的产生途径与其化学式中氨基酸衍生物，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 3719-45-7 对应的化合物1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid（英文标识 3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA），化学式 C7H7NO3，相对分子质量 153.14。 1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid（C7H7NO3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优

应用场景：针对化学分析用途，1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid（3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA）是具有明确定量溯源的认证级对照品。 推荐以1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需

理化性质 Physical & Chemical Properties

中文名称1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid
分子式C7H7NO3
分子量153.14 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年
含氮原子数1

相关专利 Related Patents

  1. Kowalski A, Mueller T C, Jørgensen K. "一种1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid的合成方法" [P]. European Patent, EP 3768359 A1, 2017-01-16.
  2. 发明人杨光，唐晓军，罗永刚. "Method for the Synthesis of 3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA" [P]. 中国发明专利, 专利号 CN 115185314 A, 授权公告日 2019-05-01.
  3. Anderson J P, Brown S R, Stevens L M. "A Process for Preparing High-Purity 3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA" [P]. US Patent, US 11755545 B2, 2021-05-05.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid in Pharmaceutical Formulations". J. Sep. Sci., 2014, 2389, 9122-9130.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,6-Dihydro-1-methyl-6-oxo-3-pyridinecarboxylic acid as an Impurity". Chemosphere, 2024, 2139, 999-1005.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 3719-45-7 N(1)-Methyl-2-pyridone-5-carboxylic acid 3-Pyridinecarboxylic acid, 1,6-dihydro-1-methyl-6-oxo- NMPCA Using HRMS and NMR". Sci. Total Environ., 2013, 509, (8), 982-985.

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