5-氟-2-硝基三氟甲苯 CAS 393-09-9
1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165
| CAS 号 | 393-09-9 |
| 分子式 | C7H9F4NO2 |
| 分子量 | 215.15 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
5-氟-2-硝基三氟甲苯（1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165，CAS 号 393-09-9）是 CATO 佳途自主生产的药物标准品，分子式 C7H9F4NO2，分子量 215.15。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
5-氟-2-硝基三氟甲苯的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C7H9F4NO2 的5-氟-2-硝基三氟甲苯（1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165），其CAS登记号是 39
应用场景：5-氟-2-硝基三氟甲苯（1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZ
理化性质 Physical & Chemical Properties
| 中文名称 | 5-氟-2-硝基三氟甲苯 |
| 分子式 | C7H9F4NO2 |
| 分子量 | 215.15 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 对光敏感，应避免强光直射；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人李文辉，胡光，郑宇鹏. "一种5-氟-2-硝基三氟甲苯的合成方法" [P]. 中国发明专利, 专利号 CN 113259511 B, 授权公告日 2024-03-13.
- 发明人郭海燕，王建平，朱建伟. "Method for the Synthesis of 1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165" [P]. 中国发明专利, 专利号 CN 115489158 A, 授权公告日 2020-07-18.
- 发明人韩伟，朱建伟，杨光. "A Process for Preparing High-Purity 1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165" [P]. 中国发明专利, 专利号 CN 113457242 B, 授权公告日 2022-02-06.
参考文献 Literature
- Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 5-氟-2-硝基三氟甲苯 in Pharmaceutical Formulations". Environ. Sci. Technol., 2020, 731, (12), 9508-9514.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-氟-2-硝基三氟甲苯 as an Impurity". J. Nat. Prod., 2021, 428, 9082-9097.
- Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165 Using HRMS and NMR". Biomed. Chromatogr., 2019, 164, (4), 8236-8263.
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