1-(乙氧基羰甲基)哌嗪 CAS 40004-08-8
1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate
| CAS 号 | 40004-08-8 |
| 分子式 | C8H16N2O2 |
| 分子量 | 172.22 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 40004-08-8 对应的1-(乙氧基羰甲基)哌嗪（1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate）为 CATO 佳途药物标准品产品线成员。分子式 C8H16N2O2，分子量 172.22。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
CAS编号 40004-08-8 对应的化合物1-(乙氧基羰甲基)哌嗪（英文标识 1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate），化学式 C8H16N2O2，相对分子质量 172.22。 1-(乙氧基羰甲基)哌嗪（C8H16N2O2）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品适用于HPLC
应用场景：在化学分析实验室中，1-(乙氧基羰甲基)哌嗪（CAS 40004-08-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-(乙氧基羰甲基)哌嗪配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮
理化性质 Physical & Chemical Properties
| 中文名称 | 1-(乙氧基羰甲基)哌嗪 |
| 分子式 | C8H16N2O2 |
| 分子量 | 172.22 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1968年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人韩伟，王建平，钱学锋. "一种1-(乙氧基羰甲基)哌嗪的合成方法" [P]. 中国发明专利, 专利号 CN 109701231 B, 授权公告日 2024-03-26.
- 发明人胡光，徐明华，唐晓军. "Method for the Synthesis of 1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate" [P]. 中国发明专利, 专利号 CN 111358932 A, 授权公告日 2024-06-26.
- Yamamoto T, Brown S R, Hughes D C. "A Process for Preparing High-Purity 1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate" [P]. US Patent, US 10023957 B2, 2023-02-27.
参考文献 Literature
- Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(乙氧基羰甲基)哌嗪 in Pharmaceutical Formulations". Molecules, 2012, 1278, (7), 113-122.
- Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(乙氧基羰甲基)哌嗪 as an Impurity". J. Nat. Prod., 2020, 633, (1), 9024-9052.
- Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 1-(ethoxycarbonylmethyl)piperazine 2-(Piperazin-1-yl)acetic acid ethyl ester 2-(piperazin-1-yl)-acetic acid ethyl ester 40004-08-8 ethyl (piperazin-1-yl)acetate ethyl 1-piperazineacetate ethyl 2-(piperazin-1-yl)acetate ethyl piperazin-1-ylacetate ethyl piperazinoacetate Using HRMS and NMR". Food Chem., 2025, 1637, (12), 92-122.
- Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 1-(乙氧基羰甲基)哌嗪 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2022, 1665, (1), 301-330.
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